【摘要】 目的 分析西安地区宫颈组织中HPV的流行状况和感染亚型分布，分析其与宫颈病变的关系，以期为西安地区宫颈癌致癌机制及HPV疫苗研制起到推动作用。方法 收集2007年10月-2009年9月间在本院进行宫颈液基细胞学检测和组织病理学检查的150例标本(包括炎症50例，CINⅠ39例，CINⅡ35例，CINⅢ 20例，宫颈鳞癌6例)，进行HPV分型分析。结果 共检测出16种HPV亚型，其中包括 11 种高危型 HPV(16，18，31，33，35，39，52，58，59，66，68型)， 3 种低危型(6、11和42型)以及2种中国人常见亚型(53型和66型)。高危型中HPV-16 型是最常见的，累计检出35例(其中单一感染17例，混合感染18例)，占感染病例的37.6%(35/93);其次是HPV- 39型，累计检出18例(其中单一感染11例，混合感染7例)，占感染病例的19.4%(18/93)，而且6例宫颈癌中有2例都有HPV-39感染;HPV-58型居第三位，累计检出8例(其中单一感染4例，混合感染4例)，占感染病例的8.6%(8/93);而在其他国家和地区中常见的HPV-18型仅在1例混合感染中存在。低危型HPV感染率最高的亚型分别是HPV-6和HPV- 11型。不同类型的宫颈组织中HPV感染亚型并未见明显差异。结论 西安地区HPV流行亚型明显不同于其他地区，通常认为流行于非洲的HPV-39在西安占到第二位。不同病理类型的宫颈组织中，高危型HPV的分布无明显差别。明确一个地区宫颈HPV流行亚型分布，可为区域特异性HPV疫苗的研制提供依据。
【关键词】 宫颈癌;人乳头瘤病毒;亚型
Distribution characteristic of HPV genotype from Xi an area and its relationship to cervix lesions
ZHANG Jian-fang,CHEN Bi-liang,SONG Hui,et al.Department of Gynaecology and Obstetrics,Xijing Hospital,Fourth Military Medical Unversity, Xi an 710000,China
[Abstract] Objective To analyze the prevailing status,genotype distribution of HPV infection and its relationship to cervix lesions,which will produce an active effect on the mechanism and HPV vaccine research of uterine cervix cancer.Methods 150 cytology specimen of uterine cervix were collected for HPV typing.Among the 150 cases,50 cases were inflammation,39 were CINⅠ,35 were CINⅡ,20 were CIN Ⅲ and 6 were squamous carcinoma of the cervix.Results 16 HPV subtype were detected,including 11 hish risk type(16，18，31，33，35，39，52，58，59，66，68)，3 low risk type(6,11 and 42) and 2 Chinese common type(53 and 66).HPV-16 was the most frequent high risk subtype,total 35 cases were detected HPV-16 infection(17 were single infection and 18 were mixed infection),which account 37.6% for infected cases;the next is HPV-39, total 35 cases were detected HPV-16 infection(11 were single infection and 7 were mixed infection),which account 19.4% for infected cases, moreover,2 of 6 squamous carcinoma
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