上海地区儿童和青少年血清瘦素水平与肥胖度 青春期发育的关系

　　【摘要】　目的　研究上海地区儿童 和青少年血清瘦素(leptin)水平与肥胖度、青春期发育的关系。方法 　用放射免疫分析法测定104例健康非肥胖男孩和118例健康非肥胖女孩(年 龄在4.8岁至20岁之间)的血清瘦素水平。结果　(1)无 论是男孩还是女孩，血清瘦素水平均与体重指数(BMI)呈正相关。在女孩，血清瘦素水平与 年龄呈正相关；而在男孩，血清瘦素水平与年龄呈负相关。(2)随着年龄的增长，青春期发 育的开始，女 孩的血清瘦素水平从Ⅰ期(Tanner分期，下同)至Ⅴ期逐步上升。男孩的血清瘦素水平则从Ⅰ 期的3.12 ng/ml上升至Ⅱ期的3.95 ng/ml后即逐步下降，在Ⅴ期达最低。(3)在Tanner Ⅰ期 和Ⅱ期，男孩与女孩的血清瘦素水平接近。但在Ⅱ期之后，两者的性别差异显著(P＜0.001)，在相同的BMI水平，男孩的血清瘦素浓 度要远低于女孩。(4)在以瘦素为因变量，BMI、性别、年龄、Tanner分期为自变量的逐步多 元回归中，BMI仍是影响瘦素浓度最为显著的因素。结论　(1)与成人相似，儿童和青少年的血清瘦素水平与BMI密切相关。(2)随着青春期发育， 女孩的血清瘦素水平逐步上升，而男孩的血清瘦素水平则在青春期发育开始后先升高后下降 ，提示瘦素在促进两性性发育上可能起一激发作用，并可能是女性完成青春期发育和维持正 常生殖功能的一个重要因素。

The relationship between serum leptin concentration and adipos ity, pubertal stage in children and adolescents from Shanghai region　

TANG Jinfeng　CHEN Mingdao　GU Weiqiong　et al

　　（Shanghai Institute of Endocrinology,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025）

　　【Abstract】　Objective　To inve stigate the relationship between serum leptin concentration and body fat, pubert al stage in children and adolescents from Shanghai region. Metho ds　Serum leptin concentration was measured by RIA in 222 heal thy non-obese children and adolescents recruited from Shanghai region (104 boys and 118 girls, age from 4.8 to 20 years). Results　(1)Serum leptin level was positively correlated with body mass index (BMI) i n both boys and girls, but was positively correleted with age in girls while neg atively in boys. (2)With the pubertal development, leptin concentration of the g irls increased steadily from Tanner stage Ⅰ to Ⅴ. But in the boys, it started from 3.12 ng/ml at Tanner stage Ⅰ and reached the peak level (3.95 ng/ml) at stage Ⅱ, then declined gradually to the nadir at stage Ⅴ. (3)During t he Tanner stage Ⅰ and Ⅱ leptin concentrations were similar in both sexes and a fter Tanner stage Ⅱ a significant gender-based difference of leptin concentrat ions was found (P＜0.001). (4)BMI was found to be the most important one among the factors which affec

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