【摘要】目的 探讨广西地区汉族、壮族IgA肾病与HLADR基因的相关性。方法 采用聚合酶链反应序列特异性引物法(PCRSSP)对87名IgA肾病患者及110名正常对照者的HLADR4、DR12基因频率进行检测。结果 壮族IgA肾病组HLADR4的基因频率高于对照组(P<0.05)，HLADR4基因阳性组持续性镜下血尿伴蛋白尿的发生率高于阴性组(P<0.05)。汉族IgA肾病组HLADR12的基因频率高于对照组(P<0.01)，HLADR12基因阳性组持续性镜下血尿伴蛋白尿的发生率高于阴性组(P<0.01)。结论 ①HLADR4基因可能是广西壮族IgA肾病的易感基因;HLADR12基因可能是广西汉族IgA肾病的易感基因。②HLADR4基因与临床表现为持续性镜下血尿伴蛋白尿的广西壮族IgA肾病相关，HLADR12基因与临床表现为持续性镜下血尿伴蛋白尿的广西汉族IgA肾病相关。③HLADR4、HLADR12基因与广西壮族、汉族IgA肾病的不良病理改变均无相关性。
【关键词】 DR12的基因 IgA肾病 PCR SSP HLA DRB1基因
Correlation between HLADR gene and IgA nephropathy of Han and Chuang nationality in Guangxi area
FENG Wei, HUANG Li, LIAO YunHua.
Urology Department, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China
【Abstract】 Objective To explore the correlation between HLADR gene and IgA nephropathy of Han and Chuang nationality in Guangxi area. Methods HLADR4 and HLADR12 gene frequency were detected in 87 patients with IgA nephropathy and 110 normal healthy controls by PCRSSP. Results HLADR4 gene frequency of Chuang nationality IgA nephropathy group was higher than that of control group(P<0.05)，the persistent microscopic hematuria accompanied with albuminuria rate of HLADR4 gene positive group was higher than that of negative group(P<0.05). HLADR12 gene frequency of Han nationality IgA nephropathy group was higher than that of control group(P<0.01)，the persistent microscopic hematuria accompanied with albuminuria rate of HLADR12 gene positive group was higher than that of negative group(P<0.01). Conclusions ①HLADR4 gene might be predisposing genes of IgA nephropathy of Guangxi Chuang nationality;HLADR12 gene might be predisposing genes of IgA nephropathy of Guangxi Han nationality. ②HLADR4 gene is related to IgA nephropathy accompanied with persistent microscopic hematuria and albuminuria of Guangxi Chuang nationality, HLADR12 gene is related to t
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