多烯磷脂酰胆碱联合复方丹参治疗非酒精性脂肪肝疗效观察

　　【摘要】 目的：观察多烯磷脂酰胆碱联合复方丹参治疗非酒精性脂肪肝的临床疗效。方法：随机选择非酒精性脂肪肝住院患者68例，其中治疗组41例，静点多烯磷脂酰胆碱10 mL及复方丹参20 mL, 1次/d;对照组27例,静点甘草酸二铵150 mg，1次/d;疗程1个月。治疗期间均不用其他保肝降酶和降血脂类药。结果：治疗组肝功能、血脂各指标显著下降，B超检查结果明显改善，与对照组相比，差异有统计学意义(P<0.05 );治疗组、对照组临床疗效总有效率分别为82.9%、66.7%，两组差异均有统计学意义(P<0.05 )。结论：多烯磷脂酰胆碱联合复方丹参治疗非酒精性脂肪肝疗效显著。

　　【关键词】 多烯磷脂酰胆碱;复方丹参;非酒精性脂肪肝;联合用药

　　The Observation of Curative Effects of Polyene Phosphatidyl Choline in Combination with

　　Compound Salvial Injection for Nonalcoholic Fatty Liver Disease

　　Guo Lili,Liu Jinchun

　　The First Affiliated Hospital of Shanxi Medical University

　　Abstract Objective:To observe the curative effects of polyene phosphatidyl choline in combination with compound salvial injection for nonalcoholic fatty liver disease.Methods:68 hospital patients with nonalcoholic fatty liver disease were enrolled in this prospective randomized study.41 cases in the treatment group received the combination of polyene phosphatidyl choline(10 mL,iv.gtt,qd) and compound salvial injection(20 mL,iv.gtt,qd),while 27 cases in the control group were treated only with diammonium glycyrrhizinate injection(30 mL/150 mg,iv.gtt,qd).The course of the treatment in both groups was one month.Any other liver function-protecting and blood lipid-lowering drugs were excluded during the treatment period. Result：The treatment group had a significantly higher excellence rate of the indexes including liver function,blood lipid and B-Ultrasonography performance,compared with the control(P<0.05 ,respectively).The total effective rate of clinical efficacy in the treatment group was 82.9% and 66.7% in the control group ,with a significant difference between the groups(P<0.05). Conclusion:the therapeutic regimen of polyene phosphatidyl choline in combination with compound salvial injection has remarkable curative effects for nonalcoholic fatty liver disease.

　　Key words Polyene phosphatidyl choline;Compound salvial injection

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