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幽门螺杆菌cagA基因3 端多态性分析及其临床意义

.Gut,2000,47(1) :18.

11 Chen XJ,Yan J,Shen YF.Dominant cagA/ vacA genotypes and coinfection frequency of H.pylori in peptic ulcer or chronic gastritis patients in Zhejiang Province and correlations among different genotypes,coinfection and severity of the diseases.Chin Med J,2005,118(6) :460.

12 Covacci A,Censini S,Bugnoli M,et al.Molecular characterization of the 128-KDa immunodominant antigen of helicobacter pylori associated with cytotoxity and duodenal ulcer.Proc Natl Acad Sci USA,1993,90:5791-5795.

13 Evans DJ,Queiroz DMM,Mendes EN,et al.Diversity in the variable region of Helicobacter pylori cagA gene involves more than simple repetition of a 102-nucleotide sequence.Biochem Biophys Res Commun,1998,245: 780-784.

14 Yamaoka Y,Kodama T,Kashima K,et al.Variants of the 3’ region of the cagA gene in Helicobacter pylori isolates from patients with diferent H.pylori-associated diseases.J Clin Microbiol,1998,36: 2258-2263.

15 Backert S,Moese S,Selbach M,et al.Phosphorylation of tyrosine 972 of the Helicobacter pylori CagA protein is essential for induction of a scattering phenotype in gastric epithelial cells.Mol Microbiol,2001,42:631-644.

16 Higashi H.Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites.Proc Natl Acad Sci USA,2002,99:14428-14433.

17 Higashi H,Yokoyama K,Fujii Y,et al.EPIYA motif is a membrane targeting signal of Helicobacter pylori virulence factor CagA in mammalian cells.J Biol Chem,2005,280(23):130-137.

18 Hwang IR,KodamaT,Kikuchi S,et al.Effect of interleukin I pobrmorphisms on Gastricmucosal interleukin Ⅰ beta production in Helicobacter pylori infection.Gastroenterology,2002,123(6):1793-1803.

19 Machado JC,Pharoah P,Sousa S,et al.Interleukin 1β and interleukin IRN polymorphisms are associated with increased risk of gastric carcinoma.Gastroeite

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