|
农村成年居民幽门螺杆菌感染的血清流行病学调查 |
| |
张祥宏 孙旭明 赵文元 严霞 王俊灵 张振国 米建民 谢同欣 王会艳 三角顺一 青木一雄
【摘要】 目的 探讨农村成年居民幽门螺杆菌(Hp)感染情况及其与血清胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)和胃泌素(GAS)水平的关系。方法 以ELISA方法对赞皇县1 504名30岁以上居民血清Hp抗体进行了检测，同时以放射免疫学方法对该组调查对象血清PGⅠ、PGⅡ、PGⅠ/PGⅡ比值和GAS水平进行了定量分析。结果 赞皇县农村成年居民血清Hp抗体阳性率为66.4%，在性别之间阳性率差异无显著性。在不同年龄组的居民中，30～50岁和70岁以上组血清Hp抗体阳性率有增高趋势，但统计学意义不明显。胃癌高发区和相对低发区居民血清Hp抗体阳性率差异不明显。血清Hp IgG抗体阳性居民血清PGⅠ、PGⅡ和GAS水平(62.3μg/L，15.45μg/L，74.00pg/ml)均明显高于Hp IgG抗体阴性者(42.1μg/L，6.40μg/L，66.00pg/ml)，P＜0.005，而血清PGⅠ/PGⅡ比值则显著低于后者(4.0∶6.6，P＜0.005)。结论 赞皇县大部分农村成年居民有Hp感染；Hp感染可影响血清PG和GAS水平。
【关键词】 幽门螺杆菌 血清流行病学 胃蛋白酶原 胃泌素
Seroepidemiological study on Helicobactor pylori infection in rural adult residents
ZHANG Xianghong,SUN Xuming,ZHAO Wenyuan,et al.
Department of Pathology,Hebei Medical University,Shijiazhuang 050017
【Abstract】 Objective To study the prevalence of Helicobactor pylori (Hp) infection in rural adult residents of China and its relation to serum levels of pepsinogen Ⅰ (PGⅠ),pepsinogen Ⅱ (PGⅡ) and gastrin (GAS). Methods Serum levels of antibodies against Hp were determined with enzyme-liked immunosorbent assay (ELISA) in 1 504 residents aged over 30 in Zanhuang County of Hebei Province, and their serum levels of PGⅠ，PGⅡ and GAS, as well as PGⅠ/PGⅡ ratio,were analyzed quantitatively, with radioimmunoassay (RIA). Results Positivity for serum Hp antibody accounted for 66.4% of the rural adults in Zanhuang County, without significant sex difference. There was no significant difference in positivity for serum Hp antibody between residents in the high and low prevalent areas of gastric cancer. Serum levels of PGⅠ,PGⅡ and GAS were significantly higher in those with positive serum IgG anti-Hp (62.3μg/L，15.45μg/L and 74.00pg/ml, respectively) than those negative (42.1μg/L，6.40μg/L and 66.00pg/ml, respectively), all with a P-value less than 0.005, and the ratio of serum PGⅠ to PGⅡ levels was significantly lower in the former (4.0) than[1] [2] 下一页
上一个医学论文： 山西省原发性肝癌丙型肝炎病毒 乙型肝炎病毒感染状况分析
下一个医学论文： 部队肺结核发病因素的病例对照研究
|
|
|
|
|
|
|
您现在的位置： 绿色健康网 >> 医学论文 >> 基础医学论文 >> 正文