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山西省原发性肝癌丙型肝炎病毒 乙型肝炎病毒感染状况分析 |
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王金桃 赵宏光 赵淑芳 李佩珍
【摘要】 目的 探讨山西地区原发性肝癌(PHC)中丙型肝炎病毒(HCV)和乙型肝炎病毒(HBV)感染状况。方法 选择以山西省肿瘤医院为主的省级4所医院PHC患者98例，检测抗-HCV、HBsAg、抗-HBs、HBeAg、抗-HBe、抗-HBc、抗-HBc IgM等指标，均采用ELISA法进行测定。结果 PHC组抗-HCV阳性率8.16%，HBV感染率68.37%，均显著高于对照组的阳性率(P＜0.05)。两者的病因分值(ARP)分别为94%和91%。经1∶2条件logistic多元回归分析，抗-HCV、HBsAg和抗-HBc均作为独立的危险因素进入了回归方程，其OR值分别为55.06、10.18和9.85。叉生分析结果表明，抗-HCV和HBsAg双阳性的OR值为61.37，较两指标单一阳性的OR值明显为高，亦高于两者单独阳性的OR值之和。结论 HCV和HBV感染均是PHC发生的主要病原学因素。HCV感染在致肝癌作用中，是当地不可忽视的重要因素，HBV仍是肝癌发生的主要因素。HBV和HCV双重感染对肝癌的发生具有协同作用。
【关键词】 原发性肝癌 丙型肝炎病毒 乙型肝炎病毒
Prevalence of HCV and HBV infection in patients with primary hepatocellular carcinoma in Shanxi Province
WANG Jintao,ZHAO Hongguang,ZHAO Shufang,et al.
Department of Epidemiology, Shanxi Medical University, Taiyuan 030001
【Abstract】 Objective To study the prevalence of hepatitis C and B viruses (HCV and HBV) infection in the patients with primary hepatocellular carcinoma (PHC) in Shanxi Province and evaluate their etiologic roles in the pathogenecity of PHC to lay a foundation for the prevention and control of it. Methods Ninety-eight patients with PHC and 196 non-PHC controls matched in age and sex were selected from the four hospitals at provincial level in Shanxi Province. Serum antibodies against HCV (anti-HCV),HBs (anti-HBs),HBe (anti-HBe) and HBc (anti-HBc), IgM-antibody against HBc (anti-HBc-IgM), HBsAg and HBeAg were determined for all of them with enzyme-linked immunosorbent assay (ELISA). Results Positivity for anti-HCV and rate of HBV infection were 8.16% and 68.37%, respectively, in the PHC patients,both significantly higher than those in the controls (P＜0.05), with attributable risk proportions of (ARP) 94% and 91%, respectively. Multiple conditional logistic regression analysis showed that positive serum anti-HCV, HBsAg and anti-HBc, as risk factors for PHC, all entered the regression model, with odds ratios (ORs) of 55.06,10.18 and 9.85,respectively. Dichotomized con[1] [2] [3] 下一页
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