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银杏内酯A对应激性溃疡发生的抑制作用 |
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张根葆 钱大青 孙俊
［摘 要］ 目的：探讨银杏内酯A (Ginkgolide A) 对大鼠应激性溃疡发生的抑制作用及其可能机制。 方法：Wistar大鼠，随机分成对照组和银杏内酯预处理组；以束缚水浸法建立应激性溃疡模型，通过胃窦部埋置电极记录应激状态下胃平滑肌自发电活动的变化，并测定血浆MDA 含量和SOD活性以及观察胃粘膜的病理学改变。 结果：银杏内酯A 5～20 mg/kg 腹腔注射预处理组，应激所致的胃肌电活动紊乱和血浆MDA 水平以及胃粘膜溃疡指数均明显低于对照组（P＜ 0.05）；而血浆SOD活性则高于对照（P＜0.01），其效应具有剂量依赖性。结论：血小板活化因子拮抗剂银杏内酯A 能明显减轻束缚水浸应激引起的大鼠胃粘膜溃疡的发生，其机制可能是通过减少自由基产生和增加其清除，改善胃平滑肌动力障碍。
［主题词］ 银杏内酯/药理学；应激；自由基；肌；电生理学；溃疡
［中图分类号］ R364.1+ 6 ［文献标识码］ A
［文章编号］ 1000-4718(2000)05-0443-03
Inhibitory effects of Ginkgolide A on stress ulceration in rats
ZHANG Gen-bao, QIAN Da-qing, SUN Jun
(Department of Physiology, Wannan Medical College, Wuhu 241001，China)
［Abstract］ AIM: To investigate the protective effects and its mechanism of Ginkoglide A on stress ulceration in rats. METHODS: Wistar rats were randomly assigned to control, and Ginkgolides pretreatment group. The stress ulceration was produced by water immersion restraint, and gastric myoelectric activity during stress was recorded by implanting electrodes in the stomach antrum smooth muscle. The malondialdehyde (MDA) concentration and superoxide dismutase (SOD) activity in plasma, and gastric mucosal lesions were examined after the rat was killed. RESULT: Compared with the control group, previous intraperitoneal administration of Ginkgolide A (5～20 mg/kg) not only had a highly significant decrease on stress-induced myoelectric activity disorder (P＜0.05), but it reduced significantly serum MDA level and increased SOD activity (P＜0.01) in concentration-dependent manner. The gastric mucosal ulceration index was also reduced significantly (P＜0.01 versus control group). CONCLUSION: Ginkgolide A, a new platelet activating factor antagonist, has a markedly inhibitory effects on gastric mucosal lesions induced by water immersion restraint stress. It's possible mechanism that Ginkgolides improve gastric myoelectric activity and reduce the production of fre[1] [2] 下一页
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