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川芎嗪对慢性低氧高二氧化碳大鼠肺动脉压力及管壁胶原的影响 |
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高志杰 王良兴 王群姬 谢于鹏 陈彦凡 陈少贤 王卫
［摘 要］ 目的：探讨川芎嗪对慢性低O2高CO2大鼠肺动脉压力及肺动脉管壁胶原的影响。方法：将SD大鼠30只分为：对照组(A)，低O2高CO2组(B)，低O2高CO2＋川芎嗪组(C)，低O2高CO2时间为4周。结果：⑴B组肺动脉平均压(mPAP)显著高于A组(P＜0.01)，C组mPAP显著低于B组(P＜0.01)，3组间平均颈动脉压无显著差异(P＞0.05)；⑵电镜显示B组肺动脉胶原纤维较A组明显为多，C组较B组明显为少。免疫组化显示B组肺动脉Ⅰ型胶原含量(平均吸光度值LD)较A组明显为高(P＜0.01),C组较B组明显为低(P＜0.01),Ⅲ型胶原LD各组间无明显差异(P＞0.05)；⑶B组血浆内皮素浓度高于A组,血清NO-2/NO-3低于A组，C组血浆内皮素浓度低于B组,NO-2/NO-3高于B组,P均＜0.01。结论：川芎嗪可预防慢性低 O2高CO2性肺动脉高压的形成和肺动脉管壁胶原的沉积。
［主题词］ 中草药；低氧；高碳酸血；高血压，肺性；胶原
［中图分类号］ R543.2； R285.5 ［文献标识码］ A
［文章编号］ 1000-4718(2000)05-0436-04
Effect of ligustrazine on pulmonary arterial pressure and pulmonary arterial wall collagen of chronic hypoxic hypercapnic rats
GAO Zhi-jie， WANG Liang-xing, WANG Qun-ji, XIE Yu-peng, CHEN Yan-fan, CHEN Shao-xian, WANG Wei
(Institute of Cor Pulmonale, Wenzhou Medical College， Wenzhou 325000, China)
［Abstract］ AIM：To study the effect of ligustrazine on pulmonary hypertensive rats induced by hypoxic hypercapnia. METHODS：Thirty rats were randomly divided into three groups:control group(A),hypoxic hypercapnic group(B), hypoxic hypercapnia+ligustrazine(lig.) group(C). RESULTS： (1) Mean pulmonary arterial pressure(mPAP)of group B was significantly higher than that of group A and mPAP of group C was significantly lower than that of group B（P＜0.01）,differences of mean carotid pressure(mCAP) were not significant among three groups (P＞0.05); (2)Electron microscopy and immunohistochemistry showed ligustrazine could inhibit the diposition of collagenous fiber(collagen typeⅠ)in pulmonary arterioles induced by hypoxic hypercapnia; (3) Plasma endothelin level of group C was significantly lower than that of group B (P＜0.01), serum (NO-2/NO-3) of group C was significantly higher than that of group B (P＜0.01). CONCLUSION：Ligustrazine can inhibit pulmonary hypertension and the diposition of collagen type Ⅰ in pulmonary arterial wall induced by hypoxic hypercapnia.
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