|
微量元素与肺癌的关系及临床应用 |
| |
赵先文1 韩存芝1 荆洁线1 郭晋纲1 朱秋娟2
摘要 为了探讨肺癌与微量元素之间的关系，采用PE3030型原子吸收分光光度计对300例肺癌、50例肺良性疾病患者及100名健康成人的血清进行了铜、锌、铁、锰、钙水平及铜/锌比值的测定。结果单因素分析表明，肺癌组、肺良性疾病组血清铜、锰的水平及铜/锌比值均明显高于健康对照组，而锌和钙则明显低于健康对照组，差异显著(分别P＜0.05～0.01)。肺癌与肺良性疾病组之间比较，被测的元素及铜/锌比值均无明显的变化(P＞0.05)。3组组内受检者职业、居住地、年龄段被测元素及铜/锌比值比较无明显的变化(P＞0.05)。结果还表明，60例化疗的肺癌患者缓解组血清铜水平及铜/锌比值与治疗前比较明显下降，而锌、钙上升，未缓解组的铜/锌比值与治疗前比较明显上升，差异有非常显著性(分别P＜0.01)。非条件logistic多因素分析表明，肺癌患者血清钙的比数比为0.9950，95%CI为0.9910～0.9990；铜/锌比值的比数比为7.9914，95%CI为3.4310～18.6134；提示血清钙可能是肺癌发病的一个保护因素；而铜/锌比值可能是个危险因素。结果还提示，以健康对照组铜/锌比值1.10为界值，对肺癌诊断阳性率为68%；并对肺癌的疗效评价有一定参考价值。
关键词 微量元素 肺癌 相关分析
Relationship of Serum Trace Elements to Lung Caner and Its Clinical Application Zhao Xianwen*, Han Cunzhi, Jing Jiexian, et al. *Dept.of Aetiology, Shanxi Cancer Institute,Taiyuan 030013
Abstract The levels of serum trace elements Cu,Zn,Fe,Mn and Ca were measured by PE3030 atomic absorption spectrophotometer in 300 patients with lung cancer,50 with nonmalignant pulmonary diseases and 100 healthy subjects. In addition, these trace elements were also measured in 60 cases with lung cancer (40 remitted, 20 non-remitted) before and after treatment. Results showed that the concentrations of serum Cu,Mn and Cu/Zn ratio were significantly higher (P＜0.01) but Zn,Ca were significantly lower (P＜0.05-0.01) in lung cancer and nonmalignant pulmonary diseases than in healthy controls. Within the three groups there has no difference among profession, area and age discovered. In the remitted patients with lung cancer, the levels of serum Cu and Cu/Zn ratio were significantly lower (P＜0.01) but Zn,Ca were significantly higher (P＜0.01) after treatment. In the non-remitted group,only Cu/Zn ratio was significantly higher (P＜0.01) after treatment. Multivariable logistic regression analysis showed that the Odds Ratio (OR) of serum Ca was 0.9950 with 95% Confidence interval (CI) 0.9910-0.9990,and the OR of Cu/Zn was 7.9914 with 95% CI 3.4310-18.6134. It was suggested [1] [2] 下一页
上一个医学论文： 江苏省1994 1995年0 14岁儿童意外死亡前瞻性调查
下一个医学论文： 中国城乡112个疾病监测点乙型肝炎疫苗接种率 免疫策略及费用调查
|
|
|
|
|
|
|
您现在的位置： 绿色健康网 >> 医学论文 >> 基础医学论文 >> 正文