莪黄糖肾合剂对早期糖尿病肾病患者尿微量白蛋白排泄率及内皮素1和一氧化氮的影响

【摘要】  　　目的 观察莪黄糖肾合剂对早期糖尿病肾病(DN)患者尿微量白蛋白排泄率（UAER）及血浆内皮素-1（ET-1）和血浆一氧化氮（NO）的影响。方法 将98例早期DN患者随机分为2组，在继续降糖治疗基础上，治疗组49例给予莪黄糖肾合剂治疗，对照组49例予贝那普利片（洛汀新）治疗，观察UAER、ET-1及NO水平变化。结果 2组治疗后UAER、ET－1均明显下降（P＜0.05)，2组间比较差异无统计学意义（P＞0.05）；治疗组NO水平明显下降，与治疗前比较差异有统计学意义（P＜0.05)；对照组治疗后NO水平虽有下降，但与治疗前比较差异无统计学意义（P＞0.05）。结论 莪黄糖肾合剂可明显降低早期DN患者UAER、ET-1和NO水平，降低早期DN患者UAER的机制与其降低ET-1、NO水平有关。

【关键词】  莪黄糖肾合剂 早期糖尿病肾病 尿微量白蛋白排泄率 内皮素-1 一氧化氮

　　Observation of Ehuangtangshen composition on urinary albumen excretion rate, ET-1 and NO in patients with early diabetic nephropathy 

　　AN Xiangping, TAN Jinchuan，DAI Jianhua．
　　Department of TCM, Collage of Shijiazhuang, Hebei, Shijiazhuang  050035

　　【Abstract】  Objective  To observe the effect of Ehuangtangshen composition on urinary albumen excretion rate (UAER), ET-1 and NO in patients with early diabetic nephropathy. Methods  98 patients with early diabetic nephropathy were randomly divided into 2 groups, the treatment group and the control group. All the cases in the both groups received treatment of controlling blood glucose. The cases in treatment group (n=49) were treated with Ehuangtangshen composition and the cases in control group (n=49) were treated with Lotensin. The therapeutic course was three months in both groups. UAER, ET-1 and NO in patients were observed before and after the treatment. Results  UAER and ET-1 in two groups significantly decreased after treatment in comparison with those before treatment (P<0.05). But there was no difference between two groups after treatment (P>0.05). The level of NO in treatment group obviously decreased after treatment compared with that before treatment (P<0.05). There was no difference between before and after treatment in control group (P>0.05). Conclusion  Ehuangtangshen composition can decrease the levels of UAER, ET-1 and NO in patients with early diabetic nephrop

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