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王晓红 唐朝枢 姚兴海 庞永政 王军 刘乃奎
［摘 要］ 目的和方法：本实验在大鼠主动脉球囊剥脱模型上，观察血浆和主动脉组织C-型利钠利尿肽(CNP)的动态变化及外源性CNP对大鼠球囊损伤后内膜生成的影响，以探讨CNP在再狭窄中的作用。结果：发现大鼠球囊损伤后血浆CNP的浓度升高，内膜剥脱后第3 d、10 d、21 d，血浆CNP水平分别增高80.7%(P＜0.01)，43.5%(P＜0.05)和27.5%(P＜0.05)，而主动脉组织CNP含量在损伤后第3 d下降46.6%(P＜0.05)，第10 d，21 d和28 d CNP含量分别增加2.8倍(P＜0.01)、1.6倍(P＜0.05)和0.82倍(P＜0.05)。外源性CNP显著抑制球囊损伤后第7 d和21 d新生内膜的形成，内膜/中膜比值分别降低22%(P＜0.05)和20%(P＜0.05)。结论：CNP参与血管球囊损伤后的修复过程，外源性CNP可抑制内膜增厚。
［主题词］ 利尿钠激素；血管成形术，气囊；大鼠
［中图分类号］ R654.2 ［文献标识码］ A
［文章编号］ 1000-4718(2000)03-0196-03
The role of C-type natriuretic peptide in balloon injury of rat aorta
WANG Xiao-hong, TANG Chao-shu, YAO Xing-hai, PANG Yong-zheng, WANG Jun, LIU Nai-kui
(Institute of Cardiovascular Research, The First Hospital, Beijing Medical University, Beijing 100034, China)
［Abstract］ AIM and METHODS: In a model of balloon injury of rat aorta, the dynamic changes of C-type natriuretic peptide (CNP) in plasma and aortic tissues and the effect of exogenous CNP on intima/media (I/M) ratios were studied. RESULTS:CNP levels in plasma were significantly increased by 80.7% (P＜0.01),43.5%(P＜0.05) and 27.5% (P＜0.05) on 3 days, 10 days and 21 days after balloon injury, but its levels in aortic tissues were decreased by 46.6% (P＜0.05) on day 3 and increased by 2.8 (P＜0.01)，1.6(P＜0.05) and 0.82-fold (P＜0.05) on day 10, day 21 and day 28 after balloon injury of rat aorta. Result also showed that the administration of CNP i.p. inhibited neointima formation. I/M ratios were decreased by 23% (P＜0.05) and 20% (P＜0.05) on 7 days, 21 days after balloon injury of rat aorta.CONCLUSION:CNP might be involved in the process of recovery after vascular endothelium-denudation and exogenous CNP suppress the neointima formation.
［MeSH］ Natriuretic hormone; Angioplasty,balloon; Rats
经皮经腔冠状动脉成形术(percutaneous transluminal coronary angioplasty, PTCA)已成为治疗冠心病的主要手段之一，然而约有30%～50%的患者术后3～6个月发生再狭窄(resten[1] [2] 下一页
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