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脑不对称 Balb c 小鼠血浆IL |
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高明霞 李康生 董菁 P.J.Neveu
摘 要：目的：研究脑不对称性对细胞因子和HPA轴的影响。方法：用伸爪取食法将小鼠区分为左利、右利、双利动物，LPS分别刺激2、4 h后取血浆用ELISA法检测IL-1β、IL-6、放免法测定血浆皮质酮含量。结果：左利组血浆IL-1β高于右利组，左利、右利组IL-1β均低于双利组。左利、右利组血浆皮质酮水平低于双利组。LPS刺激后左利组IL-1β高于右利组，双利组亦高于右利组；左利、右利组血浆IL-6水平则均低于双利组。结论：脑不对称性对神经免疫内分泌网络有影响，左利者免疫紊乱发生率高可能与此有关。
关键词：脑不对称性 神经免疫内分泌 细胞因子
分类号：R392.1
The levels of plasma IL-1β，IL-6,corticosterone of Balb/c mice with lateralization
GAO Ming-Xia
Department of Microbiology and Immunology,Shantou University Medical College, Shantou 515031
LI Kang-Sheng
Department of Microbiology and Immunology,Shantou University Medical College, Shantou 515031
DONG Jing
Department of Microbiology and Immunology,Shantou University Medical College, Shantou 515031
Abstract：Objective: To study the relationship between cytokines，HPA axis and lateralization.Methods：By using paw preference test,right-pawed ,left-pawed,ambidextrous mice model were established. ELISA kits and radioimmunoassay were used for detection of plasma levels of cytokines and corticosterone.Results:In untreated normal Balb/c mice ,left-pawed mice had a higher IL-1β level than right-pawed mice (P<0.05),while IL-1β of ambidextrous was the highest among them; There was no difference observed between the three groups in plasma levels of IL-6; As for plasma levels of corticosterone in untreated mice, left-pawed and right-pawed mice were both lower than ambidextrous mice.In LPS treated mice, plasma levels of IL-1β were higher in left-pawed mice than in right-pawed and ambidextrous mice, and right-pawed mice was lower than ambidextrous; The plasma levels of IL-6 were lower in left-pawed and right-pawed mice than in ambidextrous(P<0.01). The plasma levels of corticosterone were almost the same among the three groups after the injection of LPS. Conclusion: Lateralization could influence cytokine levels and HPA axis in mice.
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