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单纯性肥胖病人空腹和餐后血浆 |
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刘红 张巾超 李强 孙予倩
【摘要】 目的 研究单纯性肥胖病人空腹和餐后血浆β-内啡肽(β-Ep)水平变化。方法 20例肥胖症患者和12例正常对照组在隔夜空腹后，于试餐前及餐后30分钟、60分钟、120分钟和180分钟采血6ml，用放射免疫法测定血浆β-Ep、胰岛素、皮质醇和ACTH水平。结果 肥胖组基础血浆β-Ep和胰岛素水平明显高于对照组(P＜0.001和0.01)，肥胖组基础血浆β-Ep与BMI无相关性(r=0.103,P＞0.20)，肥胖组β-Ep曲线下面积与ACTH曲线下面积无相关性(r=0.132,P＞0.05)。结论 高β-Ep血症可能是与肥胖特征有关的一种现象，可将β-Ep做为肥胖症诊断的实验室参考指标之一，但不能将β-Ep作为反映肥胖症程度的指标。
【关键词】 肥胖症 β-内啡肽
Study on fasting and postprandial plasma β-endorphin levels in patients with simple obesity
LIU Hong,ZHANG Jinchao,LI Qiang,et al.
Department of Endocrinology,the Second Affiliated Hospital of Harbin Medical University,Harbin,150086
【Abstract】 Objective To investigate the fasting and postprandial plasma β-endorphin (β-Ep) levels in patients with simple obesity. Methods 20 obese patients and 12 healthy volunteers entered this study. The plasma levels of β-Ep, insulin, cortisol and ACTH at 0'、30'、60'、120'and 180' after oral mixed test meal (OMTM) were measured by RIA. Results Fasting plasma β-Ep and insulin levels were significantly higher in patients with obesity than those in controls. Plasma β-Ep levels were not correlated with BMI in obese patients (r=0.103,P＞0.20). There was no correlation between the areas under the curves of serum β-Ep and ACTH (r=0.132,P＞0.05).Conclusion The increase in the β-Ep levels might be a phenomenon in simple obesity. Serum β-Ep level may serve as a reference parameter in diagnosing obesity, but it can not reflect the degree of obesity.
【Key words】 Obesity β-endorphin
1980年Givens等首先报道了肥胖妇女血浆β-内啡肽(β-endorphin, β-Ep)水平增高，且与体重增加程度呈正相关，这一发现后来得到许多其他研究组的证实〔1-3,5,6〕。1987年，Facchinttic等进一步证实肥胖的儿童和青少年也存在高β-Ep血症，并强调了青春期肥胖者血浆β-Ep失去昼夜节律性，而皮质醇和β-LPH(β-lipoptropin)的节律性仍存在，同时还发现地塞米松对肥胖者升高的血浆β-Ep水平无抑制作用，但可使肥胖者和正常对照者的血浆ACTH、β-LPH及皮质醇浓度明显降低〔4〕。晚近，国外学者根据大量实验资料[1] [2] 下一页
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