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辛伐他汀对高血压合并动脉粥样硬化患者内皮功能的影响 |
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d hsCRP were measured before treatment in all patients. Vascular endothelial function （FMD） and carotid artery were assessed by high_resolution ultrasound technique before treatment in all patients, and all of above indicators were reviewed after 12 weeks in study group. Results Before treatment FMD in study group was significantly lower, and IMT and hsCRP were obviously higher than those in control group (P＜0.05). After 12 weeks' simvastatin therapy, the comparison of the results in study group showed significant improved (P＜0.05). In addition, it was indicated by correlation analysis that FMD was negatively related to IMT, hsCRP, SBP and TC in study group before treatment (P＜0.05). Conclusions The more serious endothelial dysfunction was observed in patients with essential hypertension (EH) combined with carotid atherosclerosis, and it correlated with multiple cardiovascular risk factors. Simvastatin could improve vascular endothelial function.
［Key words］ Essential Hypertension; Carotid Atherosclerosis; Endothelial function; C_reactive protein; Simvastatin
高血压患者出现心脑血管并发症主要与动脉粥样硬化病变有关，而动脉粥样硬化的发生是高血压、糖脂代谢异常、炎症反应以及内皮细胞功能障碍等多种因素共同作用的结果。其中，血管内皮功能障碍既参与了高血压、动脉硬化的发生、发展，同时，高血压、动脉硬化也加重了血管上一页 [1] [2] [3] [4] [5] 下一页
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