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促排卵治疗对多囊卵巢综合征患者子宫内膜整合素 v 3表达的影响 |
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王颖 陈咏健 李美芝
【摘要】 目的 了解促排卵药物对多囊卵巢综合征(PCOS)患者黄体中期子宫内膜整合素αv、β3表达的影响。方法 应用单克隆抗体，采用免疫组织化学技术对22例正常妇女、40例无排卵PCOS患者促排卵治疗后黄体中期的子宫内膜整合素αv、β3进行测定。结果 正常妇女子宫内膜整合素αv、β3表达在“着床窗口期”呈现强阳性；而氯米芬(CC)及绝经期促性腺激素(hMG)抑制αv、β3的表达，使其表达呈弱阳性；而促性腺激素释放激素激动剂对整合素αv、β3的表达无影响。结论 CC、CC/hMG促排卵周期的黄体中期子宫内膜容受性下降，整合素αv、β3表达下降或缺失。
【关键词】 子宫内膜；受体，透明连接素；卵植入； 排卵诱导； 多囊卵巢综合征
Effects of Ovulation Induction Therapies on Endometrial Integrin αv β3 Expression in Patients with Polycystic Ovarian Syndrome Related Infertility
WANG Ying, CHEN Yongjian, LI Meizhi.
Department of Obstetrics and Gynecology, The Third Clinical Hospital, Beijing Medical University, Beijing 100083， China
【Abstract】 Objective To study the endometrial integrins αvβ3 expressions during mid-luteal(ML) phase in polycystic ovarian syndrome (PCOS) related infertile patients receiving ovulation induction therapies. Methods Immunohistochemical methods using monoclonal antibody against integrins αvβ3 were performed on endometrium of ML phase obtained from 22 normal subjects and 40 PCOS related anovulatory patients who underwent ovulation induction therapy by one of the following regimens: clomiphene citrate (CC) +human chorionicgonadotropin (hCG),CC+human menopausal gonadotropin (hMG)+hCG,or gonadotropin-releasing hormone agonist +hMG+hCG. Results The expressions of endometrial integrin αvβ3 during ML phase in GnRHa +hMG+hCG cycles were similar with those in normal natural cycles, but were weaker in CC+hCG,CC+hMG +hCG cycles as compared with controls. Conclusion CC+hCG, CC+hMG+hCG regimens may induce decline of endometrial receptivity in ML phase.
【Key words】 Endometrium;Receptors, vitronectin；Ovum implantation;Ovulation induction; Polycystic ovary syndrome
随着助孕技术的发展，已经能应用促排卵药物取得较高的排卵率及卵裂率，但促排卵治疗后的妊娠率较低一直是未能解决的问题。子宫内膜仅仅有一个很短的时间容纳[1] [2] 下一页
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