|
子宫内膜异位症患者血清与腹腔液中肿瘤坏死因子 及白细胞介素6的测定 |
| |
李斌 金福明 杨来春 朱关珍
【摘要】 目的 了解子宫内膜异位症(内异症)患者血清及腹腔液中肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)的水平以及在腹腔镜保守性手术治疗后的变化。方法 收集内异症Ⅰ、Ⅱ期及Ⅲ、Ⅳ期患者各10例(共20例)的腹腔镜手术前后的血清和腹腔液，并以经腹腔镜检查确诊为与内异症无关病例10例为对照，应用放射免疫双抗体夹心法与放射免疫固相包被法分别测定其TNF-α及IL-6水平。结果 内异症患者血清和腹腔液TNF-α、IL-6水平，均与疾病分期呈正相关(r值分别为：血清：0.80，0.52；腹腔液：0.79，0.49；P均＜0.05)，且随腹腔镜保守性手术后内异灶的清除而有明显下降。结论 血清和腹腔液TNF-α、IL-6水平对术后随访、监测及手术效果的评价有重要价值。
【关键词】 子宫内膜异位症；细胞活素类；肿瘤坏死因子；白细胞介素6；腹腔镜手术
Evaluation of Tumor Necrosis Factor-alpha and Interleukin-6 Levels in Serum and Peritoneal Fluid of Patients with Endometriosis
LI Bin*, JIN Fuming*, YANG Laichun, et al.
* Department of Obstetrics, Hospital of Obstetrics and Gynecology, Shanghai Medical University, Shanghai 200011, China
【Abstract】 Objectives To evaluate the levels of tumor necrosis factor-alpha (TNF-α)and interleukin-6 （IL-6） before and after conservative laparoscopic surgery in patients with endometriosis. Methods The TNF-α and IL-6 levels in serum and peritoneal fluid of 20 endometriotic patients and 10 control patients were determined by radioimmunoassay. Results Significant parallel relationship existed between the stage of endometriosis and the TNF-α and IL-6 levels in serum and peritoneal fluid in endometriosis patients (r values: serum: 0.80,0.52; peritoneal fluid: 0.79,0.49, P<0.05). After clearance of endometriosis foci with laparoscopic conservative surgery, the TNF-α and IL-6 levels decreased significantly. Conclusion Measuring TNF-α and IL-6 level may have important value in postoperative follow-up, surveillance and evaluation of the effectiveness of surgery.
【Key words】 Endometriosis; Cytokines;Tumor necrosis factor;Interleukin-6; Laparoscopic surgery
细胞因子是由免疫活性细胞等合成和分泌的一类介导炎症和免疫反应的多肽类蛋白，在宿主抵御组织损伤过程中起重要作用，涉及机体内许多生理和病理的复杂过程，与临床许多重要疾病的发生和转归密切相关［1］。我们测定了子宫内膜异位症（内异症）患者血清和腹腔液中肿瘤坏死因子α(TNF-α)、白细胞介素6（IL-6）水平，以了解在血清与腹腔液内TNF-&alpha[1] [2] 下一页
上一个医学论文： 子宫内膜层粘连蛋白与Norplant致子宫异常出血的相关性研究
下一个医学论文： 促排卵治疗对多囊卵巢综合征患者子宫内膜整合素 v 3表达的影响
|
|
|
|
|
|
|
您现在的位置： 绿色健康网 >> 医学论文 >> 妇产科论文 >> 正文