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赖氨匹林与哌替啶治疗癌性疼痛45例 |
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陈志远 吴健华 黄珍治 李琛
摘要 目的：探讨赖氨匹林对癌性疼痛的治疗效果。方法：选择按WHO“三阶梯”止痛方案需进行第二、第三级药物治疗的患者45例，随机分为A、B、C三组。分别肌注赖氨匹林0.9g、1.8g、哌替啶50mg，观察起效时间、镇痛持续时间及副作用，用视觉模拟标尺评分法(VAS)评定镇痛效果。结果：A、B两组起效时间分别为18.1±6.2分钟和16.3±5.8分钟，慢于C组6.4±2.1分钟(P＜0.05)，镇痛持续时间分别为316.3±95分钟和418.6±85分钟，长于C组176.3±61.7分钟(P＜0.05)两组给药后20和30分钟VAS评分无显著差异(P＞0.05)。结论：赖氨匹林能有效地应用于癌痛病人第二、三级止痛，具有持续时间长、效果显著、副作用少的优点。
关键词 赖氨匹林 哌替啶 疼痛 肿瘤
Treatment of cancer pain by lysine acetylsalicylate and pethidine Chen Zhiyuan，Wu Jianhua，Huang Zhenzhi，et al．Department of Anesthesiology．The Second Affilicated Hospital， Fujian Medical University，Quan Zhou 362000
Abstract Objective ：To study the efficacy of lysine acetylsalicylate（LAS) in the relief of cancer pain．Method：Forty-five patients with cancer pain who need analgesia treatment of 2 or 3 stage according to “WHO Three Stage Analgesia Treatment Plan” were randomly divided into three groups（n=15)．Group A and B were respectively received LAS 0．9g and 1．8g intramuscularly．Group C received pethidine 50mg intramuscularly．The onset time，the duration of analgesia and side effects were observed．The degree of pain was measured with visual analogue scale（VAS）．Results：The onset time of group A（18．1±6.2 min） and group B（16．3±5．8min) were longer than that in group C（6．4±2.1min）(P＜0.05).The duration of analgesia in group A （316．3±95．9 min）and group B（418．6±85．8min）were longer than that in group C（176．3±61．7min)(P＜0.05).The VAS were no significantly differences after LAS administration between 20 and 30 min ．Conclusion：LAS i m administered can provide pain relief in patient with cancer pain，with long duration of analgesia，the satisfactory analgesic effect and slight side effects．
Key words Lysine acetylsalicylate Meperidine Pain Neoplasmas
赖氨匹林用于术后镇痛取得了满意的效果〔1，2〕。本研究目的在于探讨赖氨匹林对癌性疼痛的治疗效果，并与哌替啶比较，以期寻找一种适合癌症第二、第三级止痛治疗的非阿片类药物。
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