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系统性红斑狼疮活动期血浆降钙素基因相关肽及内皮素 |
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陶 怡
摘 要 目的：为了探讨神经肽-降钙素基因相关肽和内皮素-1在SLE活动期中的作用。方法：采用放射免疫分析法测定了34例系统性红斑狼疮病人和20例健康人血浆ET-1、CGRP水平。结果：有抗ds-DNA抗体升高和补体C3、C4下降的SLE组，ET-1水平升高(P＜0.01)，CGRP水平降低(P＜0.05)。治疗三个月后，ET-1水平无明显差异(与治疗前比P＞0.05)。CGRP有明显差异(与治疗前比P＜0.05)。直线相关分析表明，血浆ET-1与CGPR呈显著负相关。结论：提示ET-1与CGRP失衡可能是SLE活动期发生、发展的重要因素。测定血浆ET-1、CGRP水平变化可望作为判断病情严重程度和治疗好坏的一个指标。此结果为应用CGRP治疗SLE的理论提供依据。
关键词 内皮素 降钙素基因相关肽 红斑狼疮，系统性
THE CHANGE OF CGRP AND ET-1 IN SERUM DURING ACTIVITY OF SLE Tao Yi.The Second Affiliated Hospital,Guangzhou Medical College,Guangzhou,510260.
Abstract Objective:To investigate effect of CGRP and ET-1 in patients with active SLE.Methods:The plasma levels of CGRP and ET-1 in 34 patients with SLE and 20 normal controls were measured using radioimmunoassay method.Results:The patients with SLE having significantly high level of anti-dsDNA antibody and lower level of C3 and C4 have significantly increased levels of plasma ET-1 (P＜0.01) and descended levels of plasma CGRP (P＜0.05).After 3 month treatment,the plasma ET-1 level of patients with SLE has not been significantly changed (P＞0.05) and the plasma CGRP level has been significantly changed (P＜0.05).There were negative correlations between the plasma levels of ET-1 and CGRP.Conclusion:ET-1 and CGRP may play an important role in the development of active SLE.The changes of plasma levels of ET-1 and CGRP may be regarded as indicators of the disease severity and the rapeutic effect.The result may provide theoretical evidence for CGRP being used to treat the patient with SLE.
Key words endothelins calcitonin gene related peptide systemic lupus erythematosus,systemic
降钙素基因相关肽(calcitonin gene related peptide,CGRP)和内皮素-1(endothelin-1,ET-1)是两种相互拮抗的，具有多种生物学效应的神经肽，广泛分布于机体各个系统之中，它对各系统特别是心血管系统有着重要调节作用，但CGRP和ET-1与系统性红斑狼疮(systemic lupus erythematosus,SLE) 之间的关系报道甚少，我们采用放射免疫法测定了34例SLE病人CGRP、ET-1的水平，旨在探讨CGRP、ET-1在SLE发病中的作用及其临床意义。
1 资料与方法
1.1 病例选择：SLE组均为1994年8月～1996年12月我院住院和门诊患者34例，年龄[1] [2] 下一页
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