【摘要】 目的：探讨老年2型糖尿病患者同型半胱氨酸(Hcy)与胰岛素抵抗的相关性，分析高同型半胱氨酸血症(HHcy)的影响因素。方法：选取30例老年体检者作为健康对照组，同时选取符合入选标准的86例老年2型糖尿病患者按照体重指数分为正常体重组、超重组和肥胖组。留取血、尿测定Hcy及生化指标，计算体重指数(BMI)、稳态模型胰岛素抵抗指数(HOMAIR)。结果：1.各组血浆Hcy水平依次升高，F=20.134,P=0.000。2.各组间HOMAIR、BMI、FPG、FINS、HbA1c、TC、TG、HDLc、LDLc、尿Alb/Cr、BUN、收缩压(SBP)、病程有统计学差异，P<0.05。Cr、舒张压(DBP)无差别，P>0.05。3.相关分析表明Hcy与HOMAIR、BMI、FPG、HbA1c、TC、TG、HDLc、LDLc、尿Alb/Cr、Cr、SBP、DBP、病程成显著正相关，P<0.05;与BUN、FINS无相关性，P>0.05。进一步多元线性逐步回归分析显示仅HOMAIR、BMI、SBP、TC、尿Alb/Cr、Cr、FPG与血浆Hcy水平独立相关。结论:1.随着胰岛素抵抗的加重，血浆Hcy水平逐渐升高。老年2型糖尿病患者血浆Hcy水平升高与胰岛素抵抗有关。2.老年2型糖尿病患者HOMAIR、BMI、SBP、TC、尿Alb/Cr、Cr、FPG是影响血浆Hcy水平的独立相关因素。
【关键词】 糖尿病/2型;老年人;胰岛素;胰岛素抵抗;同型半胱氨酸
Investigation on Hcy and Insulin for 86 Elder Cases with Type 2 Diabete
TANG Hongxia,DONG Luling,WANG Xinfang,et al
The First Hospital,Zhangjiakou,075000,Hebei,China
【ABSTRACT】 Objective:To study the relationship between insulin resistance and homocysteine(Hcy) for the elder patients with type 2 diabetes mellitus,and analyze the same type of high Hyper homocysteinemia (HHcy) risk factors.Methods:30 cases selected from the elders were tavea as a healthy control group,86 elder cases with type 2 diabetes mellitus were divided into normal weight,overweight and superobesity group according to body mass index(BMI).Hematuria was collected with Hcy levels and other indicators,BMI and steadystate model insulin resistance index were calculated (HOMAIR).Results:1.The level of Hcy for each group increased in turn (F=20.134,P= 0.000).2.HOMAIR,BMI,FPG,FINS,HbA1c,TC,TG,HDLc,LDLc,urine Alb/Cr,BUN,systolic blood pressure (SBP),duration differences were statistically significant(P<0.05).And Cr,diastolic blood pressure (DBP) were nondiscriminatory,P>0.05.3.The correlation analysis showed that Hcy and HOMAIR,BMI,FPG,HbA1c,TC,TG,HDLc,LDLc,urine Alb/Cr,Cr,SBP,DBP were significant positive correlations,P<0.05,but a significant difference to gender,age,BUN
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