【摘要】 目的:探讨亚急性甲状腺炎患者甲状腺功能和血清胰岛素样生长因子1(IGF1)水平的变化。方法:采用放射免疫分析(RIA)检测28例经抗生素、肾上腺皮质激素和甲状腺素片治疗前后亚急性甲状腺炎患者和28名健康人(对照组) 血清IGF1和甲状腺激素水平。结果:治疗前亚急性甲状腺炎血清IGF1水平(714.02±309.74)mIU/mL明显高于对照组(211.13±39.85)mIU/mL,差异有显著性(P<0.01);亚急性甲状腺炎治疗后,患者血清IGF1水平(91.18±30.83)mIU/mL明显低于治疗前(P<0.01)，与对照组比较差异有显著性(P<0.01)。结论:亚急性甲状腺炎患者治疗前血清IGF1和甲状腺激素水平明显升高,IGF1的正常调节受到后者变化的影响;且在治疗后期IGF1水平下降有助于甲状腺功能的恢复。
【关键词】 甲状腺炎/亚急性;生长调节素类;甲状腺激素类;胰岛素样生长因子1
Changes of Serum InsulinLike Growth Factors1 Level in
Subacute Thyroiditis before and after Treatment
LIU fang1,LI Xiaojun2,SONG Guangjie3
1.The Experimental Center，Hebei North University，Zhangjiakou,075000,Hebei,China;
2.Medical Technology College,Hebei North University，Zhangjiakou,075000,Hebei,China;
3.Department of Thyroid Gland，Zhangjiakou First Hosptital，Zhangjiakou,075000,Hebei,China
【ABSTRACT】 Objective:To study the changes of serum insulinlike growth factor1 (IGF1) and thyroid hormone levels in Subacute thyroiditis.Methods:The serum IGF1 level was determined with radioimmunologic assay(RIA) in 28 cases before and after therapy with antibiotic、adrenocortical hormone and roxine in primary Subacute thyroiditis and 28 normal controls.Results:The serum IGF1 level (714.02±309.75)mIU/mL in Subacute thyroiditis was significantly higher than that of IGF1 level (211.13±39.85)mIU/mL in controls(P<0.01).The serum IGF1 level (91.18±30.83)mIU/mL in Subacute thyroiditis patients after treatment was significantly lower than that before treatment (P<0.01) and there was also difference compared with that of controls(P<0.01).Conclusion:The levels of serum IGF1 and thyroid hormone in Subacute thyroiditis markedly increase and the normal regulation of IGF1 may be influenced significantly by changes of thyroid hormone levels;and the levels of serum IGF1 decreasing help to resume thyroid function after treatment.
【KEY WORDS】 Thyroiditis/S
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