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HSV 1糖蛋白B基因疫苗体内表达的观察研究

19):197588.

  4 刘 姝,吴雅臻.人色素上皮源性因子基因真核表达载体的构建及在大鼠眼内的表达〔J〕.中国老年学杂志,2007;27(3):4156.

  5 Ramachandrandran S, Kinchinton PR. Potential prophylactic and therapeutic vaccines for HSV infections〔J〕. Curr pharm Des, 2007;13(19):196573.

  6 Pepose JS, Keadle TL, Morrison LA. Ocular herpes simplex: changing epidemiology, emerging disease patterns, and the potential of vaccine prevention and therapy〔J〕. Am J Ophthalmol, 2006;141(3):54757.

  7 Koelle DM, Corey L. Herpes simplex: insights on pathogenesis and possible vaccines〔J〕. Annu Rev Med, 2008;59: 38195.

  8 Koeelle DM. Vaccines for herpes simplex virus infections〔J〕. Curr Opin Investig Drugs, 2006 ;7(2):13641.

  9 GeibenLynn R, Greenland JR, FrimpongBoateng K, et al.CD4+ T lymphocytes mediate in vivo clearance of plasmid DNA vaccine antigen expression and potentiate CD8+ Tcell immune responses〔J〕.Blood, 2008;112(12):458590.

  10 Operschall E, Schuh T, Heinzerl L,et al. Enhancement of cellmediated immunity against viral infection by coadministration of plasmid DNA coding forvirol antigen and cytokinnes in mice〔J〕.J Clin Virol,1999;13(12):1720.

  11 Caselli E,Balboni PG,Incorvaia C, et al. Local and systemic inoculation of DNA or protein gB1sbased vaccines induce a protective immunity against rabbit ocular HSV1 infection〔J〕. Vaccine, 2001;19:122531.

  12 Nesburn AB, Slanina S, Burke R, et al. Local periocular vaccination protects against eye disease more effectively than systemic vaccination following primary ocular herpes simplex virus infection in rabbits〔J〕.J Virol,1998;72(10):771521.

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