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子宫内膜异位症与卵巢上皮性癌的关系 |
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张蕴玉 黄惠芳 连利娟 黄荣丽 郎景和
【摘要】 目的 探讨子宫内膜异位症(异位症)与卵巢上皮性癌(卵巢癌)的关系。方法 对371例卵巢癌中的20例合并异位症的病例进行回顾性分析，并与351例未合并异位症的病例（其中内膜样癌38例，透明细胞癌39例）进行对照研究。结果 20例合并异位症者中，内膜样癌11例，透明细胞癌7例，腺癌和浆液性乳头状腺癌各1例。合并异位症的卵巢癌与未合并异位症的同型卵巢癌相比较，前者细胞分化较好；应用Kaplan-Meier法计算5年生存率，前者高于后者。结论 异位症与内膜样癌和透明细胞癌关系密切，异位症病灶恶变可能是这两型卵巢癌的来源之一。异位症手术后可行药物治疗，内膜样癌和透明细胞癌治疗时可考虑应用孕激素。
【关键词】 子宫内膜异位症 卵巢肿瘤 癌
Clinical Discussion of the Relationship between Endometriosis
and Epithelial Ovarian Cance
ZHANG Yunyu, HUANG Huifang, LIAN Lijuan, et al.
Chinese Academy of Medical Science, Peking Union Medical College, Peking Union Medical College Hospital, Beijing 100730
【Abstract】 Objective To analyse the relationship between endometriosis and epithelial ovarian cancer. Methods We analyzed retrospectively the 20 cases associated with endometriosis in 371 cases of epithelial ovarian cancer, and these 20 cases were also compared with the left 351 cases not associated with endometriosis(including endomtriod carcinoma 38 cases and clear cell carcinoma 39 cases). Results Among 20 cases, endomtriod carcinoma and clear cell carcinoma were most frequently associated with endometriosis, with 11 cases and 7 cases respectively, there was also 1 case of gland carcinoma and 1 case of serous papillary carcinoma. Cases of carcinomas associated with endometriosis had higher pathological grade and 5-year survival probability(Kaplan-Meier method) than those cases not associated with endometriosis. Conclusions There is a close relationship between endometriosis and ovarian endomtriod carcinoma and clear cell carcinoma, the malignant transformation of endometriosis foci may be an important origin of them. Drug therapy is recommended for endomtriosis after the operation. In the treatment of endomtriod carcinoma and clear cell carcinoma, progestin can be used as an accessory method.
【Key words】 Endometriosis Ovarian tumor Carcinoma
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