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胎儿纤维连接蛋白与细菌性阴道病和绒毛膜羊膜炎关系的研究 |
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王冬 王振红 邸慧明 马英 王占东
【摘要】 目的 通过检测胎儿纤连蛋白(FFN)研究细菌性阴道病和绒毛膜羊膜炎的关系,为产前早期诊断绒毛膜羊膜炎提供新方法。方法 采用酶联免疫吸附法(ELISA)对细菌性阴道病患者60例(研究组),健康孕妇45例(对照组)进行宫颈阴道分泌物FFN检测。以FFN≥50 μg/L为判断阳性标准。结果 研究组FFN阳性率26.67%(16/60),明显高于对照组FFN阳性率的4.4%(2/45),两组比较,差异有极显著性(P<0.005)。研究组中FFN(阳性)者的绒毛膜羊膜炎发生率为75%(12/16),明显高于FFN(阴性)者绒毛膜羊膜炎发生率的13.65%(6/44),两组比较,差异有极显著性(P<0.001),且研究组中易发生早产和胎膜早破。结论 FFN与细菌性阴道病有关系,对产前诊断绒毛膜羊膜炎有价值,为预防胎膜早破和早产提供了有效的监测手段。 【关键词】 胎儿 纤连蛋白类 绒毛膜羊膜炎 阴道病,细菌性 产前诊断
The Relationship between Fetal Fibronectin, Bacteria Vaginosis and Chorioammionitis
WANG Dong, WANG Zhenhong, DI Huiming, et al.
The Second Hospital of Norman Berthune Medical University, Chang Chun 130041
【Abstract】 Objective To study the relationship of fetal fibronectin (FFN), Bacteria vaginosis (BV) and chorioamnionitis. To evaluate the diagnostic value of FFN for chorioamnionitis. Methods FFN was measured by enzyme-labelled immunosordent assay (ELISA) in samples of carvical secretion from 60 pregnant women with BV (study group) and 45 normal pregnant women at same gestational weeks (control group). Positive test was defined as a level of (FFN)≥50 ng/ml. Results Positive rate of FFN in pregnant women with BV was significantly higher than that in the normal control group. Incidence of chorioamnionitis and preterm labor in FFN positive cases was significantly higher than that of FFN negative cases. Conclusions Fetal fibronectin is an important marker for diagnosis and prediction of chorioamnionitis perterm labor and Premature rupture of membranes. 【Key words】 Fetus Fibronectins Chorioamnionitis Vaginosis, bacterial Prenatal diagnosis
妊娠妇女中约有15%~29%患有细菌性阴道病(BV)。Gravett[1]等报道,患BV的孕产妇胎膜感染的比例是健康者的3倍,发生早产及胎膜早破的机会是健康者的2倍[2]。目前认为,胎儿纤连蛋白(FFN)与早产关系密切,本研究从另一角度探讨FFN与BV的关系及其对绒毛膜羊膜炎诊断的价值。
资料与方法 一、研究对象 选取1998年2月至1998年10月来我院就诊的患者,研究组为BV患者60例。孕20~28周20例,孕29~32周7例,孕33~36周18例,孕32周15例。另选同孕龄相近的正常对照组45例。孕20~[1] [2] 下一页 上一个医学论文: 改良筋膜横切口保留腹壁浅静脉的临床意义 下一个医学论文: 正常单胎及双胎妊娠妇女子宫动脉血流变化的比较
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