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培哚普利和氯沙坦治疗心肌梗死抑制心肌重构的前瞻性随机对比研究 |
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ricle were observed. The parameters of LV (IVST，LVPWT，LVEDD，LVEDV，LVMI，LVEF ) were measured in all patients of the three groups with echocardiogram before and 12 months after the treatment. NYHA classification and the adverse drug effects were observed in all patients of the three groups.Results: There were no differences in baseline characteristics between the study groups. At 1-year after treatments:①perindopril and losartan treatment groups were characterized by significantly decreased IVST，LVPWT，LVEDD，LVEDV，LVMI compared with the conventional treatment group. ②Perindopril and losartan-based therapy induced greater increase in LVEF from baseline. LVEFs in losartan treatment group and perindopril treatment group were significantly increased by 8.58 (20.6%) and 8.91 (21.5%), P<0.01, as compared with those in conventional treatment group, respectively. ③NYHA classes in losartan treatment group and perindopril treatment group were significantly improved as compared to conventional treatment group. ④But there was no difference in the mainly parameters between losartan and perindopril groups. ⑤There were more cough cases in perindopril treatment group. ⑥There was higher cardiovascular mortality rate in conventional treatment group. Conclusion: We found that 1-year treatment with 4 mg/d of perindopril or 50 mg/d losartan might significantly reduce left ventricular hypertrophy and progressive left ventricular remodeling after myocardial infarction in patients with left ventricular dysfunction, improve the left ventricular systolic synchrony and left ventricular systolic function. The effect of losartan was similar to that of perindopril.
【KEY WORDS】 Perindopril; Losartan; Myocardial infarction; Chronic Congestive heart failure; Remodeling, left ventricular
#基金项目：本课题受广西自然科学基金资助（桂科文9930001）。*通讯作者：邓金龙，硕士，副主任医师，研究方向介入心脏病学。E-Mail：[email protected]
冠心病心肌梗死后将向慢性充血性心力衰竭（CHF）发展，此时肾素-血管紧张素系统（RAAS）被激活，血管紧张素Ⅱ（AngⅡ）升高，增加了水钠潴留和周围血管阻力， 上一页 [1] [2] [3] [4] [5] [6] 下一页
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