【摘要】 目的：探讨磷酸肌酸钠(CP, 里尔统)治疗心肌早期舒张功能障碍的疗效。方法：心肌舒张功能障碍患者138例，分为磷酸肌酸钠组(109例)常规治疗组(29例)，所有患者均进行常规治疗。磷酸肌酸组在常规治疗的基础上，给予CP 2g+5%葡萄糖或0.9%的氯化钠100ml静脉滴注，轻度舒张功能减低者每天1次，中度舒张功能减退者每天2次，连续7~14d为1疗程。采用彩色多普勒超声心动图检测二尖瓣口舒张早期峰值流速(E)、二尖瓣口舒张晚期峰值流速(A)，二尖瓣环舒张早期速度峰值(Ea)、二尖瓣环舒张晚期速度峰值(Aa)，计算E/A比值，Ea/Aa比值和E/Ea比值，对比治疗前后两组临床症状、体征及彩色多普勒超声心动图各指标改善情况。结果：治疗后两组患者所有症状和体征均有明显的改善(P<0.05~0.01)，且磷酸肌酸钠组临床显效率(96.2%)明显高于常规治疗组的57.1%(P<0.01)。磷酸肌酸钠组E/A比值(81.65%∶10.34%)、Ea/Aa比值(83.49%∶13.79%)、E/Ea比值(92.86%∶12.00%)的显效率均显著高于常规治疗组的(P均<0.01)。结论：磷酸肌酸钠对于改善心脏舒张功能和病情有显著疗效。
【关键词】 心力衰竭，充血性;磷酸肌酸;治疗结果
The morbidity rate of diastolic heart failure is as much as that of systolic heart failure. Furthermore, hospitalization rate of diastolic heart failure is gradually increased yearly. The prevention and treatment of heart failure has become a hot point in international cardiac study area. How to control the primary diseases which cause diastolic heart failure and correct diastolic dysfunction to prevent diastolic heart failure is particular import currently. Therefore, creatine phosphate (CP, Neoton) is used to reverse diastolic dysfunction, and reported the study effect as follows.
1. Data and Methods
1.1General data:
From Feb to Aug in year 2010, the Chronic disease department of our center accepted many patients with heart disease of different kinds, including hypertension, hypertensive heart disease,coronary heart disease (old and acute myocardial infarction, angina), sick sinus syndrome, diabetes mellitus, arteriosclerosis and valvular heart disease (based on diagnostic standards of WHO). Among these patients, a total of 138 diastolic dysfunction patients were selected according to 2007 diagnostic standards of diastolic dysfunction of European society of cardiology. In the patients, there were 93 male and 45 female whose average age was (50±6)years. In which 109 patients (73 male and 36 female)received the treatment of CP based on routine treatment [creati
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