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ESWL前后肾内血管阻力指数和尿中GAL与NAG检测的意义 |
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高福元 王存龙 张廷继 张志宏 王立明 孙云才
摘 要：目的：探讨肾内血管阻力指数(RI)和尿液中β-D半乳糖苷酶(GAL)、N-乙酰-β-D氨基葡萄糖苷酶(NAG)三者与ESWL所致肾损伤及其修复过程的关系。方法：检测50例单侧肾结石患者ESWL前后肾内血管RI和尿液中GAL与NAG。结果：ESWL后肾内血管RI显著升高(P＜0.01)，尿中NAG水平明显上升(P＜0.05)，而ESWL后1～2周时尿中GAL水平才开始升高，且GAL/NAG值呈明显的上升趋势。结论：ESWL所致肾损伤与肾内血管RI和尿中NAG水平相关，肾损伤修复时限长短与尿中GAL水平的变化相关，GAL/NAG值的变化可能是肾损伤和修复过程中最有效的临床监测指标。
关键词：肾结石 体外冲击波碎石 血管阻力 β-半乳糖苷酶 乙酰氨基葡萄糖苷酶
Changes in intrarend vascular resistance index and the
levels of NAG and GAL before and after ESWL
GAO Fu-yuan WANG Cun-long ZHANG Ting-ji
ZHANG Zhi-hong WANG Li-ming SUN Yun-chai
(Department of Urology,the Affiliated Tangshan workders Hospital Hebei Medical University,Tangshan,Hebei,063000)
Abstract：Purpose：To evaluate intrarenal vascular resistance index (RI) and the levels of β-D-galactosidase (GAL) and N-acetyl-β-D-glucosaminidase (NAG) in urine before and after ESWL.Methods：RI,the levels of NAG and GAL were measured in 50 renal lithiasis cases treated by ESWL.Results：RI in the treated kindeys and NAG in urine significantly increased after ESWL (P＜0.01),whereas,RI in the contralateral kindeys has no difference statistically before and after ESWL.About one and two weeks after ESWL the levels of GAL gradually elevated and the ratios of GAL/NAG had an increasing tendency.Conclusions：RI、NAG and GAL might seve as effective markers to treat the renovascular damage,the ratio of GAL/NAG is more sensitive than simple NAG or GAL as an indicator of the intrarenal injury and recovery after ESWL.
Key words：Kidney calculi Extracorporeal shock wave lithotripsy Vascular resistance β-Galactosidase Acetylglucosaminidase▲
应用彩色多普勒超声仪检测50例单侧肾结石病例体外冲击波碎石(ESWL)前后结石附近肾小动脉血管阻力指数(RI)的变化；同时测定尿中N-乙酰-β-D氨基葡萄糖苷酶(NAG)、β-D半乳糖苷酶(GAL)的水平，旨在探讨RI、NAG和GAL与ESWL所致肾脏损伤及其修复过程的关系，为临床诊治提供可靠的监测指标。
1 材料与方法
1.1 临床资料
本组肾结石患者50例，男37例，女13例，男∶女约2.8∶1。年龄30～61岁，平均35岁。其中左肾结石35例，右肾[1] [2] 下一页
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