|
局部缓释药丸防治开放性骨折感染的实验研究 |
| |
吴宏斌 郑启新 徐逢仁 李世谱 刘畅 阎玉华
【摘要】 目的 局部植入缓释药丸防治开放性骨折骨及软组织感染。方法 用可降解人工骨移植材料磷酸三钙承载第三代喹喏酮类广谱抗生素环丙沙星制成磷酸三钙/环丙沙星缓释药丸(TCDC)并检测其体外抑菌能力及植入兔股骨大转子后释药情况。结果 TCDC对金葡菌、大肠杆菌、绿脓杆菌等骨科感染常见致病菌有强大且持久的抑菌能力,持续时间分别大于5、51天,等于27天。TCDC周围骨及肌肉组织能长期(大于30天)保持较高药物浓度,而血中浓度极低且呈逐渐下降趋势。结论 TCDC具有防治开放性骨折感染的良好前景。
【关键词】 磷酸三钙 环丙沙星 骨折,开放性 感染
Experimental Study on Local Drug Delivery System for Treatment of Open Fractures WU Hong-bin, ZHENG Qi-xing, XU Feng-ren, et al. Emergency Center of Union Hospital, Tongji Medical University, Wuhan 430022
【Abstract】 Aim Drug delivery system (DDS) was adopted for the prophylaxis and treatment of osteomyelitis and soft tissue infection after open fractures. Methods We prepared a new DDS, tricalcium phosphate/ciprofloxacine delivery capsule (TCDC) by loading broadspectrum antibiotic: ciprofloxacine into the cylindrical cavity of biodegradable bone substitute tricalcium phosphate (TCP) and TCDC S bacteriostasis ability in vitro and in vivo were also tested. Results TCDC showed great and lasting bacteriostasis to common pathogens of orthopaedic infections, such as staphylococcus aureus, escherichia coli and pseudomonas aeruginosa, with bacteriostasis lasting more than 5 days, 51 days and 27 days respectively. In vivo study showed that high concentration of ciprofloxacine still occurred in the bone and muscle tissues surrounding TCDC which was placed in the great trochanter of rabbit and that it continued to let off ciprofloxacine for at least 30 days, while the concentration of ciprofloxacine in blood was very low and tended to reduce gradually. Conclusion TCDC can sustain a high local antibiotic concentration while the blood antibiotic concentration is very low. It may become a good method to treat infections after open fractures.
【Key words】 Tricalcium phosphate Ciprofloxacine Open fracture Infection
开放性骨折较易并发软组织感染及骨髓炎,严重感染常会影响骨折愈合。如何防治这类感染,一直是临床医师颇为关切的问题。Henry等将载抗生素的聚甲基丙烯酸甲酯(polymethylemethacryl[1] [2] 下一页
上一个医学论文： 促甲状腺素释放激素治疗实验性脊髓损伤的酶及免疫组织化学评价
下一个医学论文： 胚胎肢芽提取物对周围神经损伤后脊髓前角运动神经元的保护作用
|
|
|
|
|
|
|
您现在的位置： 绿色健康网 >> 医学论文 >> 外科论文 >> 正文