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哮喘豚鼠内皮素 心钠素含量的变化及心钠素对内皮素含量的影响 |
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戴山林 黄茂 王虹 殷凯生
［摘 要］ 目的：探讨内皮素-1(ET-1)在哮喘发病中的可能作用及心钠素(ANF)对ET-1水平的影响。方法：采用放免法测定各组豚鼠支气管肺泡灌洗液(BALF)和血浆ET-1、ANF、cGMP含量。结果：哮喘组豚鼠血浆及BALF中ET-1、ANF、cGMP均显著高于对照组；哮喘组豚鼠血浆中ANF与ET-1含量呈显著负相关(r=-0.638，P＜0.05)；BALF中ET-1与ANF含量呈高度负相关(r=-0.921，P＜0.01)。哮喘组豚鼠血浆中ANF与cGMP含量呈显著正相关(r=0.848，P＜0.01)，BALF中ANF与cGMP含量呈显著正相关(r=0.831，P＜0.01)。哮喘+重组大鼠ANF(rANF)组豚鼠停止输注rANF后30 min，血浆及BALF中ET-1水平均明显低于哮喘组。cGMP水平显著高于哮喘组。结论：ET-1在哮喘的发病中可能有重要作用，ANF抑制ET-1合成及分泌。
［主题词］ 哮喘； 内皮缩血管肽类； 心钠素； 鸟苷环-磷酸
［中图分类号］ R562.2+5 ［文献标识码］ A
［文章编号］ 1000-4718(2000)10-0906-03
Changes in endothelin-1 and atrial natriuretic
factor and the effect of atrial natriuretic factor on the change of
endothelin-1 in asthmatic guinea pigs
DAI Shan-lin HUANG Mao WANG Hong YING Kai-sheng
（Department of Pulmonary Diseases,the First Affiliated Hospital
of Nanjing Medical University,Nanjing 210029, China）
［Abstract］ AIM: To investigate the possible role of endothelin(ET-1) in asthma pathogenesis and the effect of atrial natriuretic factor (ANF) on changes of ET-1. METHODS: Measuring the contents of endothelin-1(ET-1),atrial natriuretic factor(ANF),cGMP in plasma and bronchoalveolar lavage fluid (BALF) of guinea pigs. RESULTS: The contents of ET-1, ANF and cGMP in asthma group were higher than that of the control group; There was a significant negative correlation between ET-1 and ANF(r=-0.638,P＜0.05) in plasma of the asthma group, and a significantly negative correlation between ET-1 and ANF(r=-0.921,P＜0.01) in BALF of the asthma group. There was a significantly positive correlation between ANF and cGMP(r=0.848,P＜0 .01) in plasma of the asthma group,and a significantly positive correlation between ANF and cGMP (r=0.831,P＜0.01) in BALF of the asthma group. The levels ET-1 in the asthma+rat ANF(rANF) group were lower than those in the asthma group,and the levels of cGMP in the asthma+rat ANF(rANF) group were higher than those in the asth[1] [2] [3] 下一页
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