|
高渗刺激诱导大鼠下丘脑室旁核和视上核神经激肽B受体阳性神经元表达Fos |
| |
吕葆真 丁玉强
【摘要】 目的 研究神经激肽B受体(NK3受体)与机体渗透压调节之间的可能关系。 方法 用双重免疫组织化学染色技术，高渗刺激采用静脉内注射1.5 mol/L NaCl的方法，观察了下丘脑室旁核和视上核内NK3受体阳性神经元在高渗刺激下的Fos表达情况。 结果 高渗盐水可诱导下丘脑室旁核和视上核内大量神经元表达Fos。在室旁核，双标细胞约占NK3受体阳性神经元的88%，约占Fos阳性细胞的71%；在视上核的主部，双标细胞约占NK3受体阳性神经元的74%，约占Fos阳性细胞的43%。 结论 室旁核和视上核内NK3受体阳性神经元可能参与大鼠渗透压调节过程。
【关键词】 神经激肽B受体 Fos 下丘脑室旁核 视上核 大鼠
NEUROKININ B RECEPTOR-POSITIVE NEURONS IN THE
PARAVENTRICULAR AND SUPRAOPTIC NUCLEI OF THE
HYPOTHALAMUS EXPRESS Fos AFTER INTRA-
VENOUS INJECTION OF HYPERTONIC
SALINE IN THE RAT
Baozhen, Ding YuqiangΔ
(Department of Anatomy and K.K.Leung Brain Research Center,
The Fourth Military Medical University,Xi an)
【Abstract】 Objective In order to investigate possible relation of neurokinin B receptor(NK3) with osmoregulation,expression of Fos in NK3 receptor-containing neurons in the paraventricular and supraoptic nuclei of the hypothalamus was investigated in the rat after hypertonic stimuli.Methods A double immunohistochemical staining method was used;hypertonic stimuli was done with intravenous injection of 1.5 mol/L NaCl.Results Hypertonic treatment induced Fos expression in many neurons of the paraventricular and supraoptic nuclei.In the paraventricular nucleus,about 88% of NK3 receptor-positive neurons exhibited Fos-like immunoreactivity, which corresponded to about 71% of Fos-positive neurons.In the principal part of the supraoptic nucleus,about 74% of NK3 receptor-positive neurons was Fos-like immunoreactive,which corresponded to about 43% of Fos-positive neurons.Conclusion NK3 receptor-containing neurons in the paraventricular and supraoptic nuclei might be involved in osmoregulation of the rat.
【Key words】 Neurokinin B receptor; Fos; Hypothalamic paraventricular nucleus; Supraoptic nucleus; Rat
速激肽家族主要包括P物质、K物质(又称神经激肽A)和神经激肽B(neurokinin B,NKB),它们在神经系统的功能活动中起着重要的作用［1］。速激肽的生理作用是通过它们各自相应的受体实现的，即NK1、NK2和NK3受体［2，3］。[1] [2] 下一页
上一个医学论文： 睾丸摘除后大鼠垂体前叶CGRP免疫反应神经纤维的变化
下一个医学论文： 神经激肽B受体在猫三叉神经脊束核尾侧亚核和脊髓内的分布
|
|
|
|
|
|
|
您现在的位置： 绿色健康网 >> 医学论文 >> 基础医学论文 >> 正文