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中国湖北汉族重症肌无力与HLA |
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龚非力 杨志章 熊平 徐金枝 徐勇 姜晓丹 吴雄文
S.Ferencik Yanj un Liu H.Grosse-Wilde
摘 要 目的和方法：探讨中国湖北汉族重症肌无力(MG) 患者与HLA-Ⅱ类等位基因的关联。利用PCR/SSP和PCR-RFLP技术对湖北地区91例MG患者进行 HLA-Ⅱ类(HLA-DRB1、DQB1和DPB1)基因型别分析，并与168例正常个体比较。 结果：患者组(1)：HLA-DRB1*0901、DQB1*0303和DPB1*0501等位基因频 率明显高于对照组，RR值分别为4.12、3.04和3.01，P＜0.01；(2)HLA-DPB1*0202 等位基因频率明显低于对照组，RR值为0.13，P＜0.05。结论：中国 湖北汉族群体中MG与HLA-DRB1*0202、等位基因正关联，而与HLA-DPB1*0202等位基因呈 负关联，与白种人群相比，这种关联对中国湖北汉族MG病人来说是特有的。
主题词 重症肌无力； HLA抗原；基因表达
Association of HLA class Ⅱ (DRB1/DQB1/DPB1) alleles and myasthenia
gravies in the Han nationality of Hubei province
GONG Fei-Li, YANG Zhi-Zhang, XIONG Ping, XU Jing-Zhi,
XU Yong, JIANG Xiao-Dan, WU Xiong-Wen
Department of Immunology, Tongji Medical University, Wuhan(430030)
S.Ferencik, Yanjun Liu, H. Grosse-Wilde
Institute of Immunology, Essen University, Germany
Abstract：AIM：To investigate the association of polymorphism o f HLA class Ⅱ genes (DRB1/DQB1/DPB1) with myasthenia gravies(MG). METHODS：HLA class Ⅱ alleles of 91 patients with MG and that of 168 normal individuals of Han nationality of Hubei province were typed by using PC R/SSP and PCR/RFLP.RESULTS：(1) Gene frequencies of HLA-DRB1*090 1(RR=4.12, P＜0.01), HLA-DQB10303(RR=3.04,P＜0.01) and DPB1*0501(RR =1.22,P＜0.01) are much higher in MG patients than in normal controls; (2) Gene frequencies of HLA-DPB1*0202(RR=0.12,P＜0.05) are much lower in MG pa tients than in normal controls. CONCLUSION：There is a positive co rrelation between HLA-DRB1*0901、DQB1*0303、DPB1*0501 and MG. There is a nega tive correlation between HLA-DPB1*0202 and MG. These correlations are peculiar to MG patients of the Han nationality of Hubei province, as compared with Caucas ians.
MeSH：Myasthenia gravis; HLA antigens; Gene expression
重症肌无力(myasthenia gravis, MG)属于一种自身免疫病，患者体内 产生高水平抗乙酰胆碱受体(AchR)抗体，后者与骨骼肌运动终板上AchR结合，导致骨骼肌功 能障碍。本文借助多聚酶链式反应/序列特异性引物(polymerase chain reaction/ s [1] [2] 下一页
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