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北京市4 055名健康儿童丙型肝炎血清流行病学调查 |
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陈敏 夏淑君
摘要 目的 了解北京市城区儿童中丙型肝炎的发病情况。方法 对北京市4个城区4 055名健康儿童用ELISA法进行丙型肝炎病毒抗体(抗-HCV)检测。结果 抗-HCV阳性14人,同时伴丙型肝炎病毒核糖核酸阳性4人,HCV感染率为0.35%。各城区、各年龄组、男女性儿童间HCV感染率比较差异无显著性。但有输血、注射人血球蛋白等史者与无上述历史组对比,HCV感染率差异有极显著性。14例抗-HCV阳性儿童的父母检测抗-HCV均为阴性。结论 经血传播仍为本研究儿童HCV感染的主要途径。 关键词 肝炎,丙型 肝炎病毒组,丙型
A Prevalence Study on Hepatitis C Infection in 4 055 Healthy Children of Beijing
CHEN Min*, XIA Shujun. *Beijing Children s Hospital Affiliated to Capital University of Medical Sciences,Beijing 100045
Abstract Objective To understand the prevalence of hepatitis C (HC)infection in children of urban Beijing.Methods Serum antibodies against hepatitis C virus (anti-HCV) and HCV RNA were determined with enzyme-linked immunosorbent assay (ELISA) in 4 055 healthy children under 14 years of age living in four urban districts of Beijing.Results Fourteen children were positive for anti-HCV,and four of them were positive for HCV RNA as well,with a prevalence of HCV infection of 0.35%.There was no significant difference in prevalence of HCV infection between children living in different districts and by sex and age.However,very significant difference in prevalence of HCV infection between children with history of blood transfusion and injection of human blood-derived globulin and those without it.The parents of 14 children with positive anti-HCV were all negative for it.Conclusion Blood-borne transmission still was the main route for HCV infection in children. Key words Hepatitis C Hepatitis C viruses
自1989年美国Chool等[1]首先建立了丙型肝炎病毒(HCV)特异性的检测方法以来,国内外学者对正常人群中HCV感染的情况有过一些报道[2],但对我国正常儿童中HCV感染情况的报道较少,我们于1995年1月~1996年12月对北京市4个城区4 055名正常儿童进行了丙型肝炎病毒抗体(抗-HCV)的检测,结果如下。
对象与方法
1.调查对象:出生后1天~14岁的健康男女儿童,既往无肝炎病史,调查范围为北京市西城区、宣武区、朝阳区、海淀区4个城区,涉及24所学校,8所幼儿园及部分散居儿童。 2. 检测方法: (1)每例取血3 ml,分离血清,取少量血清检测丙氨酸转氨酶(ALT),其余血清-20℃冰柜中待检。在同一实验室,由两名检验师对4 055份血清检测抗-HCV,对呈阳性反应的血清做重复检测,并做丙型肝炎病毒核糖核酸(HCV R[1] [2] 下一页 上一个医学论文: 水泥厂立窑烟气适宜除尘方法研究 下一个医学论文: 百白破
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