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抗心瓣膜蛋白抗体在风湿性心瓣膜炎中的意义 |
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李奎宝 余步云
【摘 要】 目的 针对风湿性心瓣膜炎的早期诊断，建立一项检测抗心瓣膜蛋白抗体的方法，并探讨其临床意义。方法 采用ELISA法检测抗心瓣膜蛋白抗体(AVP)，比较30例风湿性心瓣膜炎、31例风湿性心脏病、24例风湿性关节炎和40名正常人血清中AVP水平，并与抗链球菌多糖抗体(ASP)、红细胞沉降率(ESR)及C反应蛋白(CRP)作一对比。结果 风湿性心瓣膜炎组AVP水平高于其他三个组(P＜0.05)，风湿性心脏病静止组高于后两个组(P＜0.05)，而后两组间差异无显著性(P＞0.05)。风湿性心瓣膜炎组AVP阳性率高于ESR及CRP。风湿性关节炎组AVP阳性率低于ASP阳性率。结论 AVP具有判断风湿性心瓣膜炎的临床价值，且具有较ESR、CRP敏感性高的优点。
【关键词】 风湿性心脏病； 抗心瓣膜蛋白抗体； 风湿性心瓣膜炎
Significance of anti-valvular protein antibody in rheumatic valvulitis
LI Kuibao,YU Buyun.
Department of Rheumatology,Third Affiliated Hospital of Sun Yat-sen University of Medical Sciences,Guangzhou 510630,China
【Abstract】 Objective For the early diagnosis of rheumatic valvulitis,a new laboratory method was established to determine the levels of anti-valvular protein antibody (AVP),and its significence was studied.Method ELISA method was used to determine the seral levels of AVP in patients with rheumatic valvulitis,rheumatic heart disease,or rheumatic arthritis and in healthy individuals.The results were also compared with other indices(ASP,ESR and CRP).Results The AVP level of rheumatic valvulitis group was higher than that of other three groups (P＜0.05).It was also higher in rheumatic heart disease group as compared with last two groups (P＜0.05).But there was no significant difference between last two groups (P＞0.05).The positive rate of AVP in patients with rheumatic valvulitis is higher than that of ESR and CRP (P＜0.05).It was lower in rheumatic arthritis group than the positive rate of ASP.Conclusion An increased AVP level reflexes the occurrence of rheumatic valvulitis and AVP has a higher sensitivity than that of other traditional indices (ESR and CRP).
【Key words】 Rheumatic heart disease; Anti-valvular protein antibody; Rheumatic valvulitis
风湿性心瓣膜病是一临床上常见的心血管性疾病，特别是在发展中国家其发病率及致残率仍较高［1，2］。据90年代调查估计，我国现有风湿性心脏病病人至少237万人，问题仍很严重［3］。风湿性心脏病是风湿性炎症过程所致的瓣膜损害，且常常是因瓣膜炎症的反复发作，导致单个或多个瓣膜的进行性破坏，形成狭窄和([1] [2] 下一页
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