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氨氯地平和培哚普利联合治疗对高血压病患者肾功能的影响 |
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ided randomly into three groups: amlodipine (5 mg qd, n=22), perindopril (4mg qd,
n=22) and combined treatment (amlodipine 5 mg qd+perindopril 4mg qd, n=22). Treatment lasted for
24 weeks. Parameters of renal function were measured before and after treatment. Results (1) After
treatment, urinary albumin excretions were significantly less than those before treatment in all the three
groups ［urinary albumin excretion mg/24h: 68.7±29.1, 66.4±26.3 and 44.4±16.8 vs 102.8±36.4,
104.7±42.7 and 101.4±36.7 respectively, all P〈0.01; 24h urine protein g/L: 0.17±0.031, 0.17±0.044
and 0.11±0.041 vs 0.24±0.065, 0.24±0.062 and 0.23±0.066 respectively, all P〈0.01］. Magnitude
of decrease of urinary albumin excretion in the combined treatment group was higher than those in the
amlodipine and perindopril groups ［urinary albumin excretion mg/24h: 57.3±19.6 vs 35.2±14.5 and
37.4±19.3, all P〈0.05; 24h urine protein g/L: 0.11±0.043 vs 0.069±0.036 and 0.068±0.038, all P〈0.01］.
No significant difference was found between amlodipine and perindopril groups (P＞0.05). After treatment
GFR was increased in the combined treatment and perindopril groups, no significant change was observed
in the amlodipine group (123.8±17.6, 124.8±15.4, 120.9±17.4 vs 110.8±15.2, 111.9±13.1, 112.3±15.5
ml/min, P〈0.05, 〈0.05, and >0.05, respectively). (2) No significant correlation between the magnitude
of decrease of urinary albumin excreation and that of SBP or DBP was found among all the three groups
(P>0.05). Conclusion The data suggest that amlodipine combined with perindopril treatment has additive
effect on the decrease of urinary albumin excretion and protection of renal function.
【Key words】 hypertension kidney function tests amlodipine 上一页 [1] [2] [3] 下一页
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