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鲑鱼降钙素对绝经后骨质疏松症的影响 |
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梁奕铨 余斌杰 徐陶钧 邝建 杨华章 修玲玲 翁建平
【摘要】 目的 观察鲑鱼降钙素对绝经后骨质疏松症的作用。方法 鲑鱼降钙素治疗组92例，隔日肌注50U，每日加服元素钙300mg，单用钙剂治疗的对照组23例，每日服元素钙300mg。疗程6个月。结果 用药组腰2～4椎骨密度分别升高9.3%，10.6%和8.9%，髋部骨密度无改变，与此同时，血骨钙素明显升高，尿羟脯氨酸/肌酐比值明显降低。对照组用药前后无明显改变。结论 鲑鱼降钙素有改善绝经后骨质疏松病人腰椎骨密度作用，其机理与增加骨合成和降低骨吸收有关。
【关键词】 骨质疏松症 鲑鱼降钙素 骨密度 治疗
Effect of salmon calcitonin on postmenopausal osteoporosis
LIANG Yiquan,YU Binjie,XU Taojun,et al.
Department of Endocrinology,First Affiliated Hospital,Sun Yet-san University of Medical Sciences,Guangzhou,510080
【Abstract】 Objective To evaluate the efficacy of salmon calcitonin in the treatment of postmenopausal osteoporosis, regarding changes in bone mineral density and biochemical parameters. Methods A total of 115 patients completed a 6-month study. 92 patients were given 50U of synthetic salmon calcitonin (42 Miacalcic and 50 Salcatonin) i.m. every other day and 300mg of elementary calcium orally every day. 23 control patients received only 300mg of elementary calium orally every day. Results A significant increase in spinal bone mineral density (BMD) as measured by DEXA was noted in patients treated with salmon calcitonin. The gains in L2, L3 and L4 BMD after 6 months were 9.3%, 10.6% and 8.9% respectively. No significant change in the control group was found. A significant decrease in urinary hydroxyproline/creatinine ratio and a significant increase in serum bone glaprotein (BGP) were found in the treated group, as compared to the controls. Conclusion 50 U of salmon calcitonin, administered every other day, increases BMD in postmenopausal osteoporotic women and its action may relate to the inhibition of bone resorption and the stimulation of bone formation.
【Key words】 Osteoporosis Salmon calcitonin Bone mineral density Treatment
(Chin J Endocrinol Metab, 1999,15:19-22)
绝经后骨质疏松症是妇女停经后的常见病，易引起骨折。其发病与体内雌激素水平降低，骨吸收增高有关。雌激素替代治疗(HRT)是目前防治本病的常用方法，但由于副作用也限制了它的使用。临床研究[1] [2] [3] 下一页
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