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11省市队列人群心血管病发病前瞻性研究I 危险因素水平与心血管病发病的关系 |
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吴兆苏 姚崇华 赵冬 吴桂贤 王薇 刘静 曾哲淳 王文化
【摘要】 目的 探讨我国人群心血管病主要危险因素与心血管病发病的关系和相互作用。方法 采用前瞻队列研究方法,对11省市自然人群(35～64岁)共27 527人于1992年进行基线危险因素调查后每年年终进行一次面对面随访,共3年。对在随访期间发生的心血管病事件和死亡进行登记并在个体水平上对危险因素和心血管病发病率进行相关分析。结果 (1)心血管病发病率与危险因素水平相关,其中血压水平与脑卒中发病相关最显著；(2)总胆固醇与缺血型脑卒中呈正相关而与出血型脑卒中呈“U”型相关；(3)多因素(Cox回归)分析表明男女两性心血管病预测因素不尽相同。结论 我国人群心血管病危险因素普遍存在,主要是高血压、吸烟和高血糖。心血管病发病与危险因素的关系及其特征对人群防治有一定指导意义。
【关键词】 心血管疾病 发病率 危险因素 前瞻性研究
A prospective cohort study on cardiovascular disease incidence in 11 provinces of China I. Associations between risk factor level and cardiovascular disease incidence WU Zhaosu, YAO Chonghua, ZHAO Dong, et al. Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029
【Abstract】 Objective To explore the association and interrelationship between incidence of cardiovascular disease (CVD) and risk factors in Chinese population. Methods A prospective cohort study was carried out in a natural population (aged 35-64), totally 27 527 subjects. After a baseline survey for risk factors in 1992, follow-up for each subject was done at the end of each year from 1993 through 1995. All new CVD events and deaths due to CVD occurring within the follow-up period were registered.Results (1) Correlation existed between CVD incidence and risk factor levels, being the most significant between blood pressure level and stroke occurrence. (2) There was a positive correlation between total cholesterol level and ischemic stroke and a “U” shaped correlation between total cholesterol level and hemorrhagic stroke. (3) Multivariable analysis (Cox regression) showed that the predictive factors for both coronary and stroke events in males were somewhat different from that in females. Conclusion CVD and its risk factors are common in Chinese population and the most important risk factors are hypertension, smoking and hyperglycemia. The results of this study are of importance in CVD control programs in Ch[1] [2] 下一页
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