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分泌期及孕早期子宫内膜巨噬细胞及自然杀伤细胞的测定 |
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洪燕 林其德 陈珠萍 赵伟秀
摘 要：目的 探讨子宫内膜局部免疫微环境对妊娠的影响。方法 对19例孕6～9周的正常妊娠和11例正常分泌期妇女，采用流式细胞技术检测蜕膜及内膜的巨噬细胞及自然杀伤(NK)细胞。结果 蜕膜组织中巨噬细胞［白细胞分化抗原分化簇(CD)14阳性即CD+14］及NK细胞(CD56阳性即CD+56)含量较分泌期子宫内膜组织增加，差异有极显著性(P<0.01)。NK细胞的CD+56CD-16亚群含量增加，差异有极显著性(P<0.01)，而CD+56CD+16亚群含量差异无显著性（P>0.05）。结论 子宫内膜巨噬细胞及NK细胞可能参与妊娠子宫对半同种异体胚胎的保护性免疫反应。
关键词：子宫内膜；抗原，CD14；蜕膜；巨噬细胞；杀伤细胞，天然
Changes of Endometrial Macrophages and Nature Kill Cells during Luteal Phase and Early Pregnancy
HONG Yan
(Department of Gynecology and Obstetrics, Renji Hospital, Shanghai Second University, Shanghai 200001，China)
LIN Qide
(Department of Gynecology and Obstetrics, Renji Hospital, Shanghai Second University, Shanghai 200001，China)
CHEN Zhuping
(Department of Gynecology and Obstetrics, Renji Hospital, Shanghai Second University, Shanghai 200001，China)
Abstract：Objective To investigate the effect of endometrial microenvironment on pregnancy. Methods The number of macrophage and nature kill (NK) cells in decidua and endometrium were determined in 19 cases of early pregnancy and 11 non-pregnant women respectively by cytometric analysis. Results The percentages of macrophages (leukocyte antigen molecules CD14 positive) and NK cells ( CD56 positive) were significantly increased in decidua of first trimester as compared with those in luteal endometrium （P<0.O1）.The number of CD+56CD-16 subset of NK cells increased significantly during early pregnancy. While the number of CD+56CD+16 subset did not change. Conclusion The endometrial macrophages and NK cells may be involved in the mechanism of the fetal protective immune reaction during pregnancy.
Key words：Endometrium；Antigens, CD14；Decidua；Macrophages；Killer cell, natural▲
在妊娠过程中，母体对同种异体的胚胎抗原的免疫耐受，一直是生殖免疫研究的重点。随着分子免疫学的进展，与胎儿半同种异体抗原组织直接接触的子宫内膜得到越来越多的关注［1］。对子宫内膜免疫职能细胞功能的研究，主要集中于啮齿类动物模型中，目前的报道仅限于对少数正常妊娠和不明原因难免流产患者子宫蜕膜自然杀伤(NK) 细胞变化的观察［2,3］。但对正常分泌期及早孕期巨噬细胞，以及分泌期NK细胞的观察[1] [2] 下一页
上一个医学论文： 早孕妇女血清及蜕膜组织液对自然杀伤细胞活性及淋巴细胞增殖的影响
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