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中国北方儿童格林 |
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乌正赉 吴沪生 王全意 照日格图 王春勇 梁志学
单广良 崔淑兰 潘 利 郑建德 左 群 张亚利 张孔来
摘要 目的 探讨儿童格林-巴利综合征（GBS）的危险因素。方法 采用病例对照设计方法，对51例儿童GBS患者和51例对照儿童进行入户问卷调查，调查因素包括一般情况、发病诱因、家庭环境和个人卫生等方面。病例诊断根据临床症状、体征和神经电生理检查，并测定血清空肠弯曲菌IgG抗体。结果 51例患儿中有45例（88.2％)来自农村。37例患儿于病前2～4周曾有前驱症状 (72.5％)。既往脊髓灰质炎疫苗和乙型肝炎疫苗接种史的OR值分别为7.27和3.14，病前有受凉史以及到过河湖地区旅行史的OR值分别为13.75和12.20；饭前便后不洗手的OR值为6.15；51例病例中有19例的血清空肠弯曲菌IgG抗体呈阳性，而对照组只3例阳性，OR值为9.5 ，以上结果差异均有非常显著性。患儿血清空肠弯曲菌IgG抗体的吸光度均值（0.171) 较对照儿童 (0.063) 明显升高，差异有显著性。结论 儿童GBS发病与空肠弯曲菌感染及卫生状况不良有关。
关键词 多神经根神经炎 病例对照研究 弯曲杆菌，空肠
A Case-control Study on Guillain-Barre Syndrome in Children of North China
WU Zhenglai*, WU Husheng, WANG Quanyi, et al.
*Department of Epidemiology，Peking Union Medical College， Beijing 100005
Abstract Objective This study aimed at exploring the risk factors for Guillain-Barre syndrome (GBS)． Methods A case-control study design was used with 51 cases of GBS， diagnosed based on their symptoms，signs and electrophysiological examinations and exclusion of poliomyelitis and other acute flaccid paralysis，and 51 controls matched on age，sex and resident village． Serum IgG antibodies specific for Campylobacter jejuni were determined for all the subjects by enzyme-linked immunosorbent assay (ELISA) with a preparation of surface antigen of C. jejuni C1 strain isolated from the patients and prevalent in north China. Each case and control were interviewed with his / her parents or guardians by a trained interviewer using an ad hoc questionnaire，including his / her demographic information，socioeconomic status，onset of the illness，and potential risk factors in their environment and personal hygiene．Data were analyzed with SAS software release 6.04 in a microcomputer. Results GBS was associated with a few factors， such as residential areas (45 of the 51 cases living in the rural areas，accounting for 88.2％ of the total)，polio and hepatitis B vaccine immunization before onset of the illness（with ORs of 7.2[1] [2] 下一页
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