【摘要】 目的 观察不同年龄未松解包茎内板触觉小体的分布规律。方法 收集不同年龄粘连性包茎标本59例，用免疫组化方法观测每例包皮内板皱褶区、粘连区中触觉小体密度，并对各组间差异进行统计学分析。结果 19岁前触觉小体密度在粘连区与皱褶区差异无统计学意义，20岁后粘连区中触觉小体明显下降，而皱褶区仍具有较高水平。结论 性成熟前后未松解包茎内板触觉小体分布特征明显不同。粘连区触觉小体在性成熟后消失表明该区域触觉小体可能具有特殊的生理功能。
【关键词】 未松解包茎; 包皮内板; 触觉小体
Observation of Meissner s corpuscle on fused phimosis
GUO Dong, XU Shengmei, JIANG Haiyang, TAN Mingbo, LUAN Hua
(Department of Pathology, Affiliated Futian Hospital of Guangdong Medical College, Shenzhen 518033，China)
Abstract：Objective To observe the distribution of Meissner s corpuscles on fused inner plate of phimosis at different ages. Methods 59 cases of fused phimosis at different ages were collected and the specimens were stained with immunohistochemistry to calculate the densities of Meissner s corpuscle on the ridge band and fused smooth mucosa. The variable of Meissner s corpuscle density in different groups was analyzed with Chisquare test. Results There was no significant difference of Meissner s corpuscle densities on fused smooth mucosa at different ages before 19. The density of Meissner s corpuscles on fused smooth mucosa was significantly declining as becoming elder since 20, but not on the ridge band.Conclusion The distribution of Meissner s corpuscle on fused inner plate may significantly vary near before and after the age of genital maturation. Meissner s corpuscles disappearing on fused smooth mucosa at the age of sexual maturation indicates that Meissner s corpuscles on smooth mucosa might play a special physiological function.
Key words：fused phimosis; inner plate of prepuce; Meissner s corpuscle
男婴出生时生理性包茎内板与阴茎头逐渐松解而形成各种形态的包皮[1]。关于生理性包茎松解的机理目前仍不清楚，相关的研究甚少[2]。Taylor 等[3]研究发现成年包皮过长内板近包皮口处有一“皱褶区”，该区富含司职精细感觉的触觉小体(Meissner s corpuscle)，包皮内板中触觉小体的生理功能目前尚不清楚，推测它在男子性功能中可能扮演重要角色，包皮内板接近冠状沟处有一光整区，成年松解的光整区中触觉小体的密度较皱褶区明显降低。由于包皮中神经末梢不仅有神经感觉功能，还具有复杂的神经分泌功能[4]。在生理性包茎的松解过程中触觉小体的变化规律以及所发挥的生理机能，尤其是在未松解包茎中触觉小体生理机能以及分布情况，均未见相关的文献报道。本文收集不同年龄未松解包
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