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MUC6基因的一个单核苷酸多态性与胃癌没有关联

,从而对MUC6基因的表达或功能起到一定的调控作用,但我们的研究结果显示这个MUC6基因SNP与胃癌没有关联。鉴于在我国这是首次研究MUC6基因多态性与胃癌的关系,因此需要其它研究来证实我们的结果。

  【参考文献】

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  [2] Peek RM Jr,Blaser MJ.I Helicobacter pylori and gastrointestinal tract adenocarcinomas[J].Nat Rev Cancer,2002,2(1):28-37.

  [3] De Bolós C,Garrido M,Real FX.MUC6 apomucin shows a distinct normal tissue distribution that correlates with Lewis antigen expression in the human stomach[J].Gastroenterology,1995,109(3):723-734.

  [4] Reis CA,David L,Carvalho F,et al.Immunohistochemical study of the expression of MUC6 mucin and co-expression of other secreted mucins (MUC5AC and MUC2) in human gastric carcinomas [J].J Histochem Cytochem,2000,48(3):377-388.

  [5] Pigny P,Guyonnet-Duperat V,Hill AS,et al.Human mucin genes assigned to 11p15.5:identification and organization of a cluster of genes[J].Genomics,1996,38(3):340-352.

  [6] Moskaluk CA,Rumpel CA.Allelic deletion in 11p15 is a common occurrence in esophageal and gastric adenocarcinoma[J].Cancer,1998,83(2):232-239.

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