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高血压左室肥厚患者组织纤维化的血清指标观察 |
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佘强 高大中 殷跃辉 刘东 李增高 罗开良 谢运兰 李德旺
【摘要】 目的 本研究旨在通过观察高血压病患者组织纤维化血清学指标的变化,以探讨其作为心肌肥厚指标的临床价值。方法 测定高血压伴左室肥厚36例,高血压不伴左室肥厚31例及正常对照30例血清中Ⅲ型前胶原(PCⅢ)、层粘连蛋白(LN)、透明质酸(HA)的含量。并将左室心肌重量指数(LVMI)与上述各参数作相关分析。结果 高血压伴左室肥厚组较高血压不伴左室肥厚组及正常对照组的血清PCⅢ、LN、HA含量显著增高(P<0.01);血清PCⅢ、LN、HA均与LVMI呈显著正相关。结论 血清PCⅢ、LN、HA均可作为高血压左室肥厚患者组织纤维化的血清学指标,为临床诊断高血压心肌肥厚提供间接的依据。 【关键词】 高血压 肥大,左心室 心肌纤维化症
Changes of serum fibrotic markers in hypertensive patients with left ventricular hypertrophy She Qiang, Gao Dazhong, Yin Yuehui, et al. Affiliated Second &127;Hospital, Chongqing Medical University, Chongqing 400010 【Abstract】 Objective To investigate the changes of serum fibrotic indices in essential hypertensive patients.Methods Serum procollagen type Ⅲ (PCⅢ), laminin (LN) and hyaluronic acid (HA) were measured by radioimmunoassay in 36 essential hypertensive patients with left ventricular hypertrophy (LVH), 31 essential hypertensive patients without LVH and 30 healthy subjects. The correlations between left ventricular mass index (LVMI) and the parameters above mentioned were analyzed.Result Serum PCⅢ, LN and HA were significantly increased (P<0.01) in hypertensive patients with LVH as compared with those without LVH and healthy subjects. Serum PCⅢ, LN and HA positively correlated with LVMI in the group of hypertensive patients. Conclusion These findings suggest that measurements of PCIII, LN and HA may provide indirect diagnostic information on myocardial fibrosis associated with arterial hypertension. 【Key words】 hypertension hypertrophy, left ventricular myocardial fibrosis
高血压性心肌纤维化主要是心肌Ⅰ型和Ⅲ型胶原合成增加。但在心肌纤维变性过程中,除胶原成分外,非胶原性糖蛋白及蛋白聚糖等细胞外基质成分也在细胞间隙内聚积,目前虽从组织形态学和免疫组织化学上已得到证明[1],但相应的血清学生化指标报道尚少。本研究观察了血清Ⅲ型前胶原(PCⅢ)、层粘连蛋白(LN)、透明质酸(HA)在高血压心肌肥厚患者中的改变,以探讨其作为心肌纤维化时血清标志物的临床价值。
对象和方法
一、研究对象 1.高血压伴左心室肥厚组:36例,男20例,女16例,平均年龄54.5岁(39~68岁),左室心肌重量指数(LVMI)男>1[1] [2] 下一页 上一个医学论文: 依那普利 硝苯啶控释片对高血压左心室肥厚者P物质和肾素 下一个医学论文: 高血压病患者心房除极向量与左室舒张功能关系的研究
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