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男性与女性白塞病的对比研究 |
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刘湘源 李胜光 施桂英 黄次波 袁国华 黄烽
摘 要：目的 探讨不同性别的白塞病(BD)的临床特点及预后。方法 对比分析50例男性BD患者和34例女性BD患者的临床表现。结果 与女性相比，男性以发热为首发症状者较多(P＜0.05)，严重眼炎占眼受累的百分率明显高于女性(P＜0.05)，男性更多地表现为针刺反应阳性及C-反应蛋白增高(P分别小于0.05和0.01)，而关节炎/关节痛及OT试验或PPD试验的阳性率较低(P均＜0.01)。皮肤表现在男性多为结节性红斑与毛囊炎共存(P＜0.05)；而女性以单纯结节性红斑多见(P＜0.01)。对有眼受累的患者进行平均49个月的随访，发现严重眼炎导致失明的比率在男性患者明显高于女性患者(P＜0.05)。结论 男性患者往往病情较重，预后不佳。
关键词：白塞病； 男性； 女性； 对比研究
Comparative study on male and female patients with Behcet′s disease
LIU Xiangyuan LI Shengguang SHI Guiying et al
（Department of Rheumatology,General Hospital of PLA,Beijing 100853,China）
Abstract：Objective To investigate clinical characteristics and prognosis of male and female patients with BD.Method The clinical features of 50 male patients with BS (MBS) and 34 female patients with BS (FBS) were comparatively analyzed.Results As compared with FBS patients,the MBS patients were more likely to have fever as first symptom (P＜0.05),severe eye disease (P＜0.05),coexistence of folliculitis and erythema nodosum (P＜0.05),and higher positive rate of pathergy test as well as C-reactive protein (P＜0.05 or 0.01).But their arthritis or arthralgia were less common and the positive rate of 1∶10 000 OT or PPD test were relatively lower in men (P＜0.01).Among the BS patients with eye involvement,A 49-month follow-up showed that the rate of blindness owning to severe eye disease was significantly higher in men than that in women (P＜0.05).Conclusion Male sex seems to contribute to more severe disease and poor prognosis.
Key words：Behcet′s disease; Male; Female; Comparative study▲
白塞病(BD)是以口、眼、外生殖器和皮肤病变为主要表现的一种全身性风湿性疾病。好发于青壮年，男女均可受累。国外曾有报道，男性白塞病(MBD)的临床表现与女性(FBD)有某些差别，而国内尚乏类似研究。我们对50例MBS患者的临床资料进行了分析，并与34例女性白塞病(FBD)患者进行对照，现总结如下。
1 临床资料
1.1 病例选择：1982—1997年住我院的BS患者84例，其中男性50例，女性34例，均符合国际上有关白塞病的诊断标准［1］。
1.2 化验检查：入院后常规检查1∶10 000 OT试验或PPD试验，抗核抗体(ANA，间接免疫荧光)，类风湿因子(RF，乳胶凝集试验或特种蛋白检测仪)，红细胞沉降[1] [2] 下一页
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