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狼疮肾炎患者血清sFas和sFasL的变化 |
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戴勇 王沙燕 齐晖 黄瑞芳 李体远 张阮章 罗秀霞
摘 要：目的 研究狼疮肾炎患者血清sFas和sFasL的变化及意义。方法 采用双抗体夹心酶联免疫吸附法(ELISA)检测正常对照18例和狼疮肾炎患者45例血清sFas和sFasL水平。结果 狼疮肾炎患者sFas和sFasL水平分别为(14±7)μg/L和(0.07±0.04)μg/L，与正常对照组(2.9±1.2)μg/L和(0.05±0.01)μg/L相比，差异有高度显著性意义(P＜0.01)。活动期sFas水平较缓解期明显增高，分别是(17±7)μg/L和(9±4)μg/L，P＜0.01；但sFasL活动期与缓解期差异无显著意义。狼疮肾炎血清sFas水平在白细胞减少、贫血、大量蛋白尿、肾功能减退、补体降低、ANA和抗RNP-Ab阳性时升高；而sFasL仅在肾功能异常时减低，与其他指标没有明显相关性。结论 sFas及sFasL参与了狼疮肾炎的发生，sFas可作为狼疮肾炎的活动性实验室指标。
关键词：狼疮肾炎； 可溶性Fas； 可溶性Fas配体； 细胞凋亡
Change and significance of serum soluble Fas (APO-1,CD95) and soluble Fas ligand in lupus nephritis
DAI Yong WANG Shayan QI Hui et al
（Department of Rheumatic Nephropathy,Shenzhen People′s Hospital,Shenzhen 518020,China）
Abstract：Objective To investigate the change and significance of serum soluble Fas (sFas) and soluble Fas ligand (sFasl) in lupus nephritis (LN).Method Levels of sFas and sFasL in 42 LN patients and 18 healthy controls were determined by a sandwich ELISA.Results The sFas and sFasL levels in 45 patients with LN were (14±7)μg/L and (0.07±0.04)μg/L，respectively,and significantly higher compared with 18 normal controls (2.9±1.2)μg/L and (0.05±0.01)μg/L,P＜0.01.The level of sFas in active LN patients was significantly higher than that of the inactive LN patients,P＜0.01.But there was no significant difference in sFasL level between active LN and inactive LN patients,P＞0.05.The sFas levels of LN patients with leukopenia,anaemia,proteinuria,hypocomplementemia,positive ANA and anti-RNP-Ab positive were significantly higher than those of LN patients with negative above indexes.Conclusion sFas and sFasL levels are significantly increased in the patients with LN,which may be play an important role in the pathogenesis of LN,and sFas can be an index of LN activity.
Key words：Lupus nephritis; Soluble Fas; Soluble Fas ligand; A[1] [2] 下一页
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