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局部释放肝素的生物降解性支架的初步实验研究 |
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乔树宾 高润霖 史瑞文 宋来凤
李永利 唐承君 孟亮 袁伟民
【摘要】 目的 探讨携带肝素的生物降解性支架预防再狭窄的作用。方法 应用已内酯和混旋丙交酯共聚物制成支架，并携带肝素，植入7只小型猪的颈动脉，观察不同时间的造影及病理改变。结果 6只植入成功。植入成功者，1只因颈动脉破裂、支架内血栓形成死亡。3只动物分别于1个月(n=2)和2个月(n=1)处死，造影均未发现狭窄，光镜下仅见轻度内膜增生，扫描电镜观察支架表面已完全内皮化。2个月处死的另外2只动物造影显示狭窄，光镜下可见明显的平滑肌细胞增生。所有动物未见明显的异物反应。结论 这种生物降解性支架，同时作为局部释放肝素的装置，可成功地植入颈动脉，对于其预防再狭窄的价值有待于进一步研究。
【关键词】 支架 肝素
Initial experimental study on a novel polymeric local heparin delivery stent Qiao Shubin, Gao Runlin, Shi Ruiwen, et al. Cardiovascular Institute & Fu Wai Hospital, PUMC, CAMS, Beijing 100037
【Abstract】 Objective To approach a new method for prevention of restenosis following balloon angioplasty. Methods A novel balloon expandable biodegradable stent made from copolymer of caprolactone (CL) and D, L-lactide (LA) was developed, in which heparin was reserved inside. The initial experimental study was undergone in 7 mini swine carotid artery models. Angiographic and pathological changes were observed. Results stents were successfully deployed in 6 of the animals. One animal died of rupture of carotid artery and subacute thrombosis in the stent. In 3 animals no stenosis was found by angiography at 1 month (n=2) and 2 months (n=1) after the procedure, only mild neointimal proliferation was seen by light microscope (LM) and endotheliazation was observed by scanning electromicroscope (SEM). In 2 animals stenosis was detected by angiography and significant smooth muscle cell proliferation in neointima was observed by LM at 2 months. No significant reaction of foreign body was observed within 2 months. Conclusion This novel polymeric stent which also acts as a local heparin delivery device can be successfully deployed into carotid artery. It may be worthy for this device to be further improved and to be studied on its value in prevention of balloon angioplasty restenosis.
【Key words】 stents heparin
临床上血管内金属支架的应用可有效地防治经皮冠状动脉腔内成形术(PTCA)[1] [2] 下一页
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