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肝素联合华法林治疗脑静脉窦血栓形成12例临床探讨 |
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sp;750u/h,aPTT of 1cases reached 1.5 times in 24 hours,3 cases add the dose of heparin to 1 000 u/h.During using medicine, platelet and fibrinogen were checked every day. 7 cases appeared suggillation at the skin of intravenous injection, bleeding time of 11 cases extended after withdrawal of needles,1 cases appeared gingiva bleeding ,without alimentary canal or other part bleeding. 7 days rechecking cranium CT, 2 cases appeared Intracal punctate hemorrhage with absence of symptoms.7 cases recovered completely, 4 cases improved significantly, 1 case improved. Followup 3 months to 2 years,there was no recurrence. Conclusion Beginning with heparin 1000u/h,which can rapidly attain a effective anticoagulation,aslo easily exceed margin of safety that may lead to over anticoagulation..We observed that heparin and warfarin treatment simultaneous in CVST had good therapeutic effect.
Key words: Cerebral venous sinus thrombosis(CVST); Heparin; Warfarin
脑静脉窦血栓形成（CVST）是缺血性脑血管病中少见类型，多数累及青壮年，起病急，进展快，,早期文献报道死亡率高达30%~80%，近期由于诊断水平的提高以及开展溶栓抗凝治疗，死亡率下降至6%~15%[1]，但具体治疗方案尚无统一意见。2004年以来，我院对CVST病人采用普通肝素联合华法林进行抗凝治疗，效果良好。
1 临床资料
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