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急性脑梗死患者中性粒细胞活化的研究 |
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【摘要】 目的 探讨中性粒细胞活化在急性脑梗死疾病患者中的意义。方法 抽取急性血栓形成性脑梗死患者及健康志愿者外周血，运用流式细胞技术检测中性粒细胞表面黏附分子CD 62L和CD 11b/CD 18表达。运用放射免疫分析检测血浆IL6、IL8、TNFα水平，用酶联免疫吸附试验检测血浆IL10水平。结果 相对于正常组，脑梗死组中性粒细胞CD 11b/CD 18平均阳性表达率显著升高(P<0.001)；CD 62L平均阳性表达率明显降低；细胞因子水平均明显升高(P<0.001)。结论 在急性血栓形成性脑梗死的急性期，中性粒细胞处于活化状态。以细胞黏附为表现的中性粒细胞活化加快了血栓的进程，可能是血栓形成的重要发病原因之一。
【关键词】 急性血栓形成性脑梗死； 中性粒细胞活化； 细胞黏附； 细胞因子
Significance of Neutrophil Activation on Polymorphonuclear Neutrophil in Patients with Acute Cerebral infarction
YUAN Ping, ZHOU Jing, ZHOU XiangYu.
(The Affiliated Hospital, Luzhou Medical College, Luzhou,646000,China)
Abstract: Objective To study the significance of polymorphonuclear neutrophil activation in patients with acute cerebral infarction.Methods Forty never treated cerebral infarction (CI) subjects have been selected to the study, thirty healthy subjects were studied as control groups. Expression of CD 62L and CD 11b/CD 18 on PMN were analyzed by flow cytometry(FCM). Radioimmuno assay(RIA) were used to detect plasma level of IL6, IL8, and TNFα, Enzymelinked immunosorbent assay (ELISA) were used to measure plasma level of IL10.Results The average positive expression percentage of CD 1[1] [2] [3] [4] [5] [6] 下一页
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