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肿瘤坏死因子 G252A C804A基因多态性与脑梗死的关系 |
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【摘要】 目的 探讨肿瘤坏死因子β(TNFβ)G252A、C804A 多态性与脑梗死(CI)的相关性。方法 采用PCR RFLP及PCRSSP技术研究88例CI患者(CI组)、81例健康者(对照组)TNFβ G252A、C804A 多态性频率。结果 CI组TNFβ C804A基因型(CC型18.2%、CA型47.7%、AA型34.1%)与对照组(38.3%、42.0%、19.7%)相比差异有统计学意义(P<0.05);其中CI组AA频率为34.1%,对照组为19.7%,两者有显著性统计学意义(P<0.05);CA+AA基因型CI的风险度为2.101(95%CI为1.048~2.954);CI组CC基因型为18.2%,对照组为38.3%,两组有显著性统计学意义(P<0.05);CI组TNFβ G252A基因型频率与对照组比较差异无统计学意义(P>0.05)。结论 TNFβ 804A等位基因可能是CI的重要易感基因, 而804C等位基因可能是其保护性因素。TNFβ G252A基因多态性可能与CI无相关性。 【关键词】 脑梗死; 肿瘤坏死因子β; 聚合酶链反应; 基因多态性
Association Between Polymorphisms of Tumor Necrosis Factorbeta and Cerebral Infarction
TU Chuanqing, YU Zhuoli, WANG Xiaobi, XU Bo.
(Department of Heamatology, Baoan People’s Hospital, Shenzhen 518101,China)
Abstract: Objective To investigate the association between polymorphism of tumor necrosis factorbeta and cerebral infarction(CI).Methods Polymerase chain reaction restriction fragment length polymorphism (PCR RFLP) and sequence specific primer PCR (PCRSSP) were used for the detection of TNFbeta genotype in 86 patients with CI and 81 healthy controls.Results The frequencies of CC, CA and AA genotypes of C804A in CI group and control were 18.2% and 47.7%, 34.1% and 38.3%, 42.0% and 19.7%,&n[1] [2] [3] [4] [5] [6] 下一页 上一个医学论文: 妊娠期糖尿病患者血小板参数变化意义的探讨 下一个医学论文: 急性脑梗死患者中性粒细胞活化的研究
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