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乌拉地尔对高血压病的疗效及安全性研究 |
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康健 张家利 高秉新 闫立荣 范军 赵菁
摘要：目的 应用动态血压监测及实验室检查评价乌拉地尔对高血压病的疗效以及安全性。方法 25例高血压病患者停用降压药物，安慰剂治疗，1周后口服乌拉地尔60mg，Bid，疗程4周。应用乌拉地尔前后进行动态血压监测及血糖、血脂、尿酸、肝肾功能、胰岛素水平检测。结果 用乌拉地尔4周后与用药前相比，患者收缩压、舒张压均明显下降(P＜0.01)，血糖、血脂、肝肾功能、血尿酸及糖负荷后60分钟、120分钟血胰岛素水平未受影响，而空腹胰岛素水平降低(P＜0.01)。结论 乌拉地尔是一种安全有效的抗高血压药物，对血糖、血脂、尿酸及肝肾功能无影响，能改善胰岛素抵抗。
关键词：乌拉地尔 高血压
Study on clinical effects and safety of ebrantil for patients with hypertension
Kang Jian
(Department of Cardiology, Beijing Ji Shui Tan Hospital,Beijing 100035)
Zhang Jiali
(Department of Cardiology, Beijing Ji Shui Tan Hospital,Beijing 100035)
Gao Bingxin
(Department of Cardiology, Beijing Ji Shui Tan Hospital,Beijing 100035)
Abstract：In order to evaluate the effect of ebrantil by ABPM technique and laboratory examination in 25 patients with hypertension before and after treatment with ebrantil. Blood glucose,blood lipid,hepatic and renal function,uric acid and plasma insulin were measured. 4 weeks after treatment, SBP and DBP dropped significantly (P＜0.01),blood glucose of 0,60 and 120 minutes,blood insulin of 60 and 120 minutes after oral glucose load and blood lipid level,hepatic and renal function, uric acid were not significantly different before and after treatment(P＜0.05),while the fasting blood insulin level was lower than that in pre-treatment(P＜0.01).It is concluded that ebrantil is a safe,effective and tolerable antihypertion agent. Laboratory examination shows that ebrantil could improve insulin resistance and has no influence on hepatic and renal function,blood lipid,blood glucose and uric acid.
Key words：Ebrantil Hypertension▲
乌拉地尔是一种较新的降压药物，它的药理作用为阻滞血管突触后α1-肾上腺素受体和刺激中枢神经α2-肾上腺受体作用，具有明显的降压作用，它的血药浓度高峰为服药后4～6小时，半衰期为4.7小时。我们通过动态血压检查(ABPM)观察乌拉地尔对血压的动态影响及该药对血糖、血脂、尿酸代谢及肝肾功能、胰岛素抵抗的影响。
资料及方法
一、对象
根据WHO/ISH标准选择高血压病人25例，其中男13例，女12例，年龄60～82岁，平均67.0±4.2岁，高血压病程2～20年，高血压Ⅰ期4例，Ⅱ期8例，Ⅲ期13例，[1] [2] 下一页
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