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儿童幽门螺杆菌相关性胃十二指肠疾病的药物治疗研究 |
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terial agent, i.e., amoxicillin (AMO), 20 mg/kg bid for group A, metronidazole (Met), 9 mg/kg bid group C and: furazolidone (FUR), 2 mg/kg bid for group D, for one week. Group B was given a standard triple therapy (CBS+AMO+Met, the same dosage as mentioned above) for two weeks. Gastroscopy was performed in these patients prior to medication and over 4 weeks after therapy and Hp infection was detected by culture and histology or by 13 C-urea breath test (13C-UBT) over 4 weeks after the therapy. All the patients completed the whole study.Results (1) The eradication rates of Hp were as follows: group A: 54 % (21/39); group B: 81 % (47/58); group C: 93 % (42/45) and group D: 91 % (122/134). The eradication rates of group C and D were about 10 % higher than group B. The differences were highly significant (χ2=34.730, P<0.001). (2) The comparison among the 4 groups showed that group A had poorest effect, while group D had the highest eradicationrate (χ2=3.847, P<0.05). (3) Within 3 days, 1 and 2 weeks after therapy, the pain relief rates in groups A, C, and D were 75 %, 90 % and 95 %, respectively. (4) The side effects in the 4 groups (nausea, vomiting, diarrhea and a few rashes) were mild. Their occurrence rate was the lowest in group A (5 %) followed by group C (7 %) and group D (8 %); the highest (9 %) was seen in group B. The symptoms caused by the side effects disappeared when the medication was completed. Conclusion Satisfactory effect was achieved in treatment of Hp-related gastrodudenal disease after the eradication of Hp in the children studied. Low dose triple therapy with CBS, CLA and Met or FUR for a week was highly effective and well tolerated in treatment of Hp-related gastritis in children. The side effects were minor. The symptoms of gastritis were well relieved. Therefore, the triple therapy composed of CBS, CLA and Met seemed to be of great value and worthy of clinical application.
【Key words】 Helicobacter pylori; Gastritis; Child; 上一页 [1] [2] [3] 下一页
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