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子宫平滑肌和胎膜组织表皮生长因子受体mRNA表达水平与分娩发动的关系 |
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陈健美 曾文洁 吴佳捷 谌兵来
摘 要：目的 探讨子宫平滑肌和胎膜组织表皮生长因子受体(EGFR)mRNA表达水平与分娩发动的关系。方法 用半定量逆转录聚合酶链反应检测分娩发动前、后各10例产妇子宫平滑肌和胎膜组织的EGFR mRNA表达水平。结果 子宫平滑肌EGFR mRNA表达水平由分娩发动前的0.91±0.32增高至分娩发动后的1.33±0.23，两者比较，差异有显著性(P<0.05)；胎膜组织EGFR mRNA表达水平由分娩发动前的1.05±0.30增高至分娩发动后的1.65±0.71，两者比较，差异有显著性(P<0.05)。结论 分娩发动前、后子宫平滑肌及胎膜组织中EGFR mRNA表达水平升高；并与分娩发动有密切关系，是诱发子宫平滑肌收缩的重要因素。
关键词：受体，表皮生长因子-尿抑胃素；子宫；胎盘；分娩发作
Correlation between Epidermal Growth Factor Receptor Messenger RNA Expression and the Onset of Labor
CHEN Jianmei
(Departrnent of Obstetrics and Gynecology, The Second Affiliated Hospital, Hunan Medical University, Changsha 410008, China)
ZENG Wenjie
(Departrnent of Obstetrics and Gynecology, The Second Affiliated Hospital, Hunan Medical University, Changsha 410008, China)
WU Jiajie
(Departrnent of Obstetrics and Gynecology, The Second Affiliated Hospital, Hunan Medical University, Changsha 410008, China)
Abstract：Objective To study the correlation between epidermal growth factor receptor messenger RNA expression and the onset of labor. Method Semiquantitative reverse transcriptase polymerase chain reaction,using GAPDH as internal standard,was applied to determine the levels of epidermal growth factor receptor messenger RNA in human myometrium (n=20) and fetal membranes (n=20) before and during labor. Results In myometrium,epidermal growth factor receptor messenger RNA increased from 0.91±0.32 before labor to 1.33±0.23 after the onset of labor (P<0.05).In fetal membranes, epidermal growth factor receptor messenger RNA increased from 1.05±0.30 before labor to 1.65±0.71 after the onset of labor (P<0.05). Conclusion The study indicates it is Up-regulation of epidermal growth factor receptors messenger RNA expression in myometrium and fetal membrane before and after the onset of labor.
Key words：Receptos, epidermal growth factor-urogastr[1] [2] 下一页
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